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1ic9

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[[Image:1ic9.gif|left|200px]]
 
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==NMR SOLUTION STRUCTURE OF THE DESIGNED BETA-SHEET MINI-PROTEIN TH10AOX==
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The line below this paragraph, containing "STRUCTURE_1ic9", creates the "Structure Box" on the page.
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<StructureSection load='1ic9' size='340' side='right'caption='[[1ic9]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1ic9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IC9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IC9 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=DPR:D-PROLINE'>DPR</scene></td></tr>
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{{STRUCTURE_1ic9| PDB=1ic9 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ic9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ic9 OCA], [https://pdbe.org/1ic9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ic9 RCSB], [https://www.ebi.ac.uk/pdbsum/1ic9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ic9 ProSAT]</span></td></tr>
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</table>
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'''NMR SOLUTION STRUCTURE OF THE DESIGNED BETA-SHEET MINI-PROTEIN TH10AOX'''
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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==Overview==
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Here we report the creation of a predominantly beta-structured mini-protein motif. The design target is based on the naturally occurring toxin hand (TH) motifs that are composed of four disulfide bonds and three loops that form a 'hand'. Analysis and subsequent modification of several generations of mini-proteins produced the final 29-residue mini-protein. The structured motif of this new mini-protein provides insight into the compensatory changes that result in the formation of a tightly packed hydrophobic core in a small, globular beta-structure motif. Additionally, this mini-motif represents a new, distinct surface topology for protein design and a valuable, yet compact, model system for the study of beta-sheet structure in water.
Here we report the creation of a predominantly beta-structured mini-protein motif. The design target is based on the naturally occurring toxin hand (TH) motifs that are composed of four disulfide bonds and three loops that form a 'hand'. Analysis and subsequent modification of several generations of mini-proteins produced the final 29-residue mini-protein. The structured motif of this new mini-protein provides insight into the compensatory changes that result in the formation of a tightly packed hydrophobic core in a small, globular beta-structure motif. Additionally, this mini-motif represents a new, distinct surface topology for protein design and a valuable, yet compact, model system for the study of beta-sheet structure in water.
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==About this Structure==
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Design of a discretely folded mini-protein motif with predominantly beta-structure.,Ottesen JJ, Imperiali B Nat Struct Biol. 2001 Jun;8(6):535-9. PMID:11373623<ref>PMID:11373623</ref>
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IC9 OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Design of a discretely folded mini-protein motif with predominantly beta-structure., Ottesen JJ, Imperiali B, Nat Struct Biol. 2001 Jun;8(6):535-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11373623 11373623]
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</div>
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[[Category: Imperiali, B.]]
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<div class="pdbe-citations 1ic9" style="background-color:#fffaf0;"></div>
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[[Category: Ottesen, J J.]]
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== References ==
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[[Category: Three stranded antiparallel beta-sheet mini-protein motif de novo protein design]]
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<references/>
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 19:50:17 2008''
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Synthetic construct]]
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[[Category: Imperiali B]]
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[[Category: Ottesen JJ]]

Current revision

NMR SOLUTION STRUCTURE OF THE DESIGNED BETA-SHEET MINI-PROTEIN TH10AOX

PDB ID 1ic9

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