This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


2gmc

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (12:37, 10 January 2024) (edit) (undo)
 
(13 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2gmc.jpg|left|200px]]
 
-
{{Structure
+
==Structure of C12-LF11 bound to the DPC micelles==
-
|PDB= 2gmc |SIZE=350|CAPTION= <scene name='initialview01'>2gmc</scene>
+
<StructureSection load='2gmc' size='340' side='right'caption='[[2gmc]]' scene=''>
-
|SITE=
+
== Structural highlights ==
-
|LIGAND= <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene> and <scene name='pdbligand=DAO:LAURIC ACID'>DAO</scene>
+
<table><tr><td colspan='2'>[[2gmc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GMC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GMC FirstGlance]. <br>
-
|ACTIVITY=
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-
|GENE=
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DAO:LAURIC+ACID'>DAO</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
-
}}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gmc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gmc OCA], [https://pdbe.org/2gmc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gmc RCSB], [https://www.ebi.ac.uk/pdbsum/2gmc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gmc ProSAT]</span></td></tr>
-
 
+
</table>
-
'''Structure of C12-LF11 bound to the DPC micelles'''
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/TRFL_HUMAN TRFL_HUMAN] Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate.<ref>PMID:12535064</ref> <ref>PMID:22320386</ref> Lactotransferrin has antimicrobial activity which depends on the extracellular cation concentration.<ref>PMID:12535064</ref> <ref>PMID:22320386</ref> Lactoferroxins A, B and C have opioid antagonist activity. Lactoferroxin A shows preference for mu-receptors, while lactoferroxin B and C have somewhat higher degrees of preference for kappa-receptors than for mu-receptors.<ref>PMID:12535064</ref> <ref>PMID:22320386</ref> The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity.<ref>PMID:12535064</ref> <ref>PMID:22320386</ref> Isoform DeltaLf: transcription factor with antiproliferative properties and inducing cell cycle arrest. Binds to DeltaLf response element found in the SKP1, BAX, DCPS, and SELH promoters.<ref>PMID:12535064</ref> <ref>PMID:22320386</ref>
-
 
+
== References ==
-
==About this Structure==
+
<references/>
-
2GMC is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GMC OCA].
+
__TOC__
-
 
+
</StructureSection>
-
==Reference==
+
[[Category: Large Structures]]
-
The acyl group as the central element of the structural organization of antimicrobial lipopeptide., Japelj B, Zorko M, Majerle A, Pristovsek P, Sanchez-Gomez S, Martinez de Tejada G, Moriyon I, Blondelle SE, Brandenburg K, Andra J, Lohner K, Jerala R, J Am Chem Soc. 2007 Feb 7;129(5):1022-3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17263370 17263370]
+
[[Category: Synthetic construct]]
-
[[Category: Protein complex]]
+
[[Category: Japelj B]]
-
[[Category: Japelj, B.]]
+
-
[[Category: DAO]]
+
-
[[Category: NH2]]
+
-
[[Category: helix]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 17:06:24 2008''
+

Current revision

Structure of C12-LF11 bound to the DPC micelles

PDB ID 2gmc

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2gmc"
Personal tools