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Band 3

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(New page: ==Band 3== <StructureSection load='4yzf' size='340' side='right' caption='Band 3 dimer' scene=''> Anion exchanger 1 (AE1), also known as band 3 or SLC4A1, exchanges chloride and bicarbonat...)
Current revision (09:04, 16 January 2024) (edit) (undo)
 
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==Band 3==
==Band 3==
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<StructureSection load='4yzf' size='340' side='right' caption='Band 3 dimer' scene=''>
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<StructureSection load='7rtm' size='340' side='right' caption='Rabbit Band 3 dimer PDB code [[7rtm]].' scene=''>
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Anion exchanger 1 (AE1), also known as band 3 or SLC4A1, exchanges chloride and bicarbonate across the red blood cell membrane, assisting in removing carbon dioxide from tissues. It also anchors the membrane skeleton <ref>PMID:34669510</ref>.
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__TOC__
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==Function==
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'''Anion exchanger 1''' (AE1), also known as '''band 3''' or '''SLC4A1''' or '''Band 3 anion transport protein''' or '''anion exchange protein''' exchanges chloride and bicarbonate across the red blood cell membrane, assisting in removing carbon dioxide from tissues. It also anchors the membrane skeleton <ref>PMID:34669510</ref>. Band 3's name comes from its appearance as the third major band on SDS-PAGE of red blood cell membrane proteins <ref>PMID: 4326772</ref>.
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Its function has been studied for more than 150 years; even so, the first complete structure was not published until 2015 <ref>PMID: 26542571</ref>, and the first crystals grown without addition of an antibody were grown on the International Space Station <ref> PMID: 30118660</ref>.
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==Disease==
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Mutations in AE1 can cause distal renal tubular acidosis<ref> PMID:15649129</ref>.
== Structural highlights ==
== Structural highlights ==
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This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
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Band 3 functions as a <scene name='96/962946/Dimer_inside_outside/1'>dimer</scene>. Each monomer contains fourteen transmembrane segments, as well as an intracellular domain that plays a gating role and a small extracellular domain.
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==3D structures of anion exchange protein==
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[[Anion exchange protein 3D structures]]
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</StructureSection>
 
== References ==
== References ==
<references/>
<references/>
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</StructureSection>
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[[Category:Topic Page]]

Current revision

Band 3

Rabbit Band 3 dimer PDB code 7rtm.

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Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Ann Taylor

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