8wdt

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "8wdt" [edit=sysop:move=sysop])
Current revision (10:11, 17 January 2024) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 8wdt is ON HOLD
+
==Crystal structure of the human adenosine A2A receptor in complex with photoresponsive ligand photoNECA(blue)==
 +
<StructureSection load='8wdt' size='340' side='right'caption='[[8wdt]], [[Resolution|resolution]] 3.34&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[8wdt]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8WDT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8WDT FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.34&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=WCH:(2S,3S,4R,5R)-5-(6-amino-2-((E)-phenyldiazenyl)-9H-purin-9-yl)-N-ethyl-3,4-dihydroxytetrahydrofuran-2-carboxamide'>WCH</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8wdt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8wdt OCA], [https://pdbe.org/8wdt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8wdt RCSB], [https://www.ebi.ac.uk/pdbsum/8wdt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8wdt ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/AA2AR_HUMAN AA2AR_HUMAN] Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Rational synthetic expansion of photoresponsive ligands is important for photopharmacological studies. Adenosine A(2A) receptor (A(2A)R) is stimulated by adenosine and related in Parkinson's disease and other diseases. Here, we report the crystal structure of the A(2A)R in complex with the novel photoresponsive ligand photoNECA (blue) at 3.34 A resolution. PhotoNECA (blue) was designed for this structural study and the cell-based assay showed a photoresponsive and receptor selective characteristics of photoNECA (blue) for A(2A)R. The crystal structure explains the binding mode, photoresponsive mechanism and receptor selectivity of photoNECA (blue). Our study would promote not only the rational design of photoresponsive ligands but also dynamic structural studies of A(2A)R.
-
Authors:
+
Crystal structure reveals the binding mode and selectivity of a photoswitchable ligand for the adenosine A(2A) receptor.,Araya T, Matsuba Y, Suzuki H, Doura T, Nuemket N, Nango E, Yamamoto M, Im D, Asada H, Kiyonaka S, Iwata S Biochem Biophys Res Commun. 2023 Dec 20;695:149393. doi: , 10.1016/j.bbrc.2023.149393. PMID:38171234<ref>PMID:38171234</ref>
-
Description:
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
[[Category: Unreleased Structures]]
+
</div>
 +
<div class="pdbe-citations 8wdt" style="background-color:#fffaf0;"></div>
 +
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Mus musculus]]
 +
[[Category: Araya T]]
 +
[[Category: Asada H]]
 +
[[Category: Im DH]]
 +
[[Category: Iwata S]]

Current revision

Crystal structure of the human adenosine A2A receptor in complex with photoresponsive ligand photoNECA(blue)

PDB ID 8wdt

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/8wdt"
Personal tools