Bupivacaine
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Bupivacaine, marketed under the brand name Marcaine among others, is a medication used to decrease feeling in a specific area. In nerve blocks, it is injected around a nerve that supplies the area, or into the spinal canal's epidural space. It is available mixed with a small amount of epinephrine to increase the duration of its action.<ref name="a5">[https://www.drugs.com/monograph/bupivacaine-local.html "Bupivacaine Hydrochloride".] The American Society of Health-System Pharmacists. Archived from the original on 2015-06-30. Retrieved August 1, 2015.</ref> See also [https://en.wikipedia.org/wiki/Bupivacaine Bupivacaine]. | Bupivacaine, marketed under the brand name Marcaine among others, is a medication used to decrease feeling in a specific area. In nerve blocks, it is injected around a nerve that supplies the area, or into the spinal canal's epidural space. It is available mixed with a small amount of epinephrine to increase the duration of its action.<ref name="a5">[https://www.drugs.com/monograph/bupivacaine-local.html "Bupivacaine Hydrochloride".] The American Society of Health-System Pharmacists. Archived from the original on 2015-06-30. Retrieved August 1, 2015.</ref> See also [https://en.wikipedia.org/wiki/Bupivacaine Bupivacaine]. | ||
| - | Bupivacaine binds to the intracellular portion of voltage-gated sodium channels and blocks sodium influx into nerve cells, which prevents depolarization. Without depolarization, no initiation or conduction of a pain signal can occur. | + | Bupivacaine binds to the intracellular portion of voltage-gated sodium (Nav) channels and blocks sodium influx into nerve cells, which prevents depolarization. Without depolarization, no initiation or conduction of a pain signal can occur. |
<scene name='10/1023607/Cv/3'>Human Nav1.7 in complex with bupivacaine</scene> ([[8i5b]]). | <scene name='10/1023607/Cv/3'>Human Nav1.7 in complex with bupivacaine</scene> ([[8i5b]]). | ||
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| + | <scene name='10/1023607/Cv/4'>Bupivacaine binding site</scene>. | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
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References
- ↑ "Bupivacaine Hydrochloride". The American Society of Health-System Pharmacists. Archived from the original on 2015-06-30. Retrieved August 1, 2015.
