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ATP-citrate synthase

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(New page: {{STRUCTURE_3pff| PDB=3pff | SIZE=400| SCENE= |right|CAPTION=ATP-citrate synthase complex with ADP and tartrate, 3pff }} ATP-citrate synthase (ACS) is part of the citrate cycle. It...)
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{{STRUCTURE_3pff| PDB=3pff | SIZE=400| SCENE= |right|CAPTION=ATP-citrate synthase complex with ADP and tartrate, [[3pff]] }}
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<StructureSection load='3pff' size='350' side='right' scene='47/477091/Cv/1' caption='ATP-citrate synthase complex with ADP (stick model), tartrate and Mg+2 ions (green), [[3pff]]'>
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ATP-citrate synthase (ACS) is part of the citrate cycle. It catalyzes the transformation of ADP, acetyl-CoA and oxaloacetate to ATP, citrate and CoA.
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== Function ==
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{{TOC limit|limit=2}}
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'''ATP-citrate synthase''' (ACS) or '''ATP citrate lyase''' or '''citryl-CoA synthetase''' is part of the citrate cycle. It catalyzes the transformation of ADP, acetyl-CoA and oxaloacetate to ATP, citrate and CoA. ACS is the link between energy metabolism from carbohydrates to the production of fatty acids.
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See also [[Citrate Synthase]]<br />
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[[Citric acid cycle intermediates serve as substrates for biosynthetic processes]]<br />
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[[Reverse Krebs cycle]].
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== Structural highlights ==
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Crystal structures have shown that tartrate and citrate bind to ACS in the same binding site. <scene name='47/477091/Cv/4'>Binding site of tartrate</scene> of ATP-citrate synthase. Water molecules are shown as red spheres. <scene name='47/477091/Cv/6'>Binding site of ADP and Mg+2 ions</scene>, [[3pff]]. <ref>PMID:22102020</ref>
== 3D Structures of ATP-citrate synthase ==
== 3D Structures of ATP-citrate synthase ==
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[[ATP-citrate synthase 3D structures]]
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[[3mwd]] – hACS + citrate – human<br />
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</StructureSection>
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[[3mwe]] – hACS + tartrate<br />
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[[3pff]] - hACS + tartrate + ADP
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

ATP-citrate synthase complex with ADP (stick model), tartrate and Mg+2 ions (green), 3pff

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References

  1. ↑ Sun T, Hayakawa K, Fraser ME. ADP-Mg2+ bound to the ATP-grasp domain of ATP-citrate lyase. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Oct 1;67(Pt 10):1168-72., Epub 2011 Sep 24. PMID:22102020 doi:10.1107/S1744309111028363

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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