ATP-citrate synthase

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (09:45, 21 January 2024) (edit) (undo)
 
(20 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_3pff| PDB=3pff | SIZE=400| SCENE= |right|CAPTION=ATP-citrate synthase complex with ADP (stick model), tartrate and Mg+2 ions (green), [[3pff]] }}
+
<StructureSection load='3pff' size='350' side='right' scene='47/477091/Cv/1' caption='ATP-citrate synthase complex with ADP (stick model), tartrate and Mg+2 ions (green), [[3pff]]'>
== Function ==
== Function ==
-
'''ATP-citrate synthase''' (ACS) is part of the citrate cycle. It catalyzes the transformation of ADP, acetyl-CoA and oxaloacetate to ATP, citrate and CoA. ACS is the link between energy metabolism from carbohydrates to the production of fatty acids.
+
'''ATP-citrate synthase''' (ACS) or '''ATP citrate lyase''' or '''citryl-CoA synthetase''' is part of the citrate cycle. It catalyzes the transformation of ADP, acetyl-CoA and oxaloacetate to ATP, citrate and CoA. ACS is the link between energy metabolism from carbohydrates to the production of fatty acids.
-
See also [[Citrate Synthase]]
+
See also [[Citrate Synthase]]<br />
 +
[[Citric acid cycle intermediates serve as substrates for biosynthetic processes]]<br />
 +
[[Reverse Krebs cycle]].
 +
== Structural highlights ==
 +
 +
Crystal structures have shown that tartrate and citrate bind to ACS in the same binding site. <scene name='47/477091/Cv/4'>Binding site of tartrate</scene> of ATP-citrate synthase. Water molecules are shown as red spheres. <scene name='47/477091/Cv/6'>Binding site of ADP and Mg+2 ions</scene>, [[3pff]]. <ref>PMID:22102020</ref>
== 3D Structures of ATP-citrate synthase ==
== 3D Structures of ATP-citrate synthase ==
 +
[[ATP-citrate synthase 3D structures]]
-
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+
</StructureSection>
-
 
+
-
[[3mwd]] – hACS + citrate – human<br />
+
-
[[3mwe]] – hACS + tartrate<br />
+
-
[[3pff]] - hACS + tartrate + ADP
+
-
 
+
 +
== References ==
 +
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

ATP-citrate synthase complex with ADP (stick model), tartrate and Mg+2 ions (green), 3pff

Drag the structure with the mouse to rotate

References

  1. ↑ Sun T, Hayakawa K, Fraser ME. ADP-Mg2+ bound to the ATP-grasp domain of ATP-citrate lyase. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Oct 1;67(Pt 10):1168-72., Epub 2011 Sep 24. PMID:22102020 doi:10.1107/S1744309111028363

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

Retrieved from "http://52.214.119.220/wiki/index.php/ATP-citrate_synthase"
Personal tools