ATP-citrate synthase
From Proteopedia
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== Function == | == Function == | ||
| - | '''ATP-citrate synthase''' (ACS) is part of the citrate cycle. It catalyzes the transformation of ADP, acetyl-CoA and oxaloacetate to ATP, citrate and CoA. ACS is the link between energy metabolism from carbohydrates to the production of fatty acids. | + | '''ATP-citrate synthase''' (ACS) or '''ATP citrate lyase''' or '''citryl-CoA synthetase''' is part of the citrate cycle. It catalyzes the transformation of ADP, acetyl-CoA and oxaloacetate to ATP, citrate and CoA. ACS is the link between energy metabolism from carbohydrates to the production of fatty acids. |
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| + | See also [[Citrate Synthase]]<br /> | ||
| + | [[Citric acid cycle intermediates serve as substrates for biosynthetic processes]]<br /> | ||
| + | [[Reverse Krebs cycle]]. | ||
| - | See also [[Citrate Synthase]] | ||
== Structural highlights == | == Structural highlights == | ||
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</StructureSection> | </StructureSection> | ||
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| - | == 3D Structures of ATP-citrate synthase == | ||
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| - | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
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| - | [[3mwd]], [[5tde]] – hACS + citrate – human<br /> | ||
| - | [[5tdf]], [[5tet]] – hACS + citrate derivative<br /> | ||
| - | [[5teq]] – hACS N-terminal (mutant) + citrate <br /> | ||
| - | [[5te1]] – hACS N-terminal (mutant) + citrate derivative<br /> | ||
| - | [[5tes]] – hACS + citrate + ADP<br /> | ||
| - | [[5tdm]] – hACS + citrate derivative + ADP<br /> | ||
| - | [[3mwe]] – hACS + tartrate<br /> | ||
| - | [[3pff]], [[5tdz]] - hACS + tartrate + ADP<br /> | ||
== References == | == References == | ||
<references/> | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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References
- ↑ Sun T, Hayakawa K, Fraser ME. ADP-Mg2+ bound to the ATP-grasp domain of ATP-citrate lyase. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Oct 1;67(Pt 10):1168-72., Epub 2011 Sep 24. PMID:22102020 doi:10.1107/S1744309111028363
