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Tiotropium bromide
From Proteopedia
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| - | <StructureSection load='' size='340' side='right' caption=' | + | <StructureSection load='' size='340' side='right' caption='Tiotropium bromide' scene='10/1013887/Cv/2'> |
Tiotropium bromide, sold under the brand name Spiriva among others, is a long-acting bronchodilator (LAMA: long acting muscarinic antagonist) used in the management of chronic obstructive pulmonary disease (COPD) and asthma.<ref name="a10">[https://www.drugs.com/monograph/tiotropium.html "Tiotropium Bromide Monograph for Professionals".] Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 14 October 2018. Retrieved 31 January 2019.</ref><ref name="a11">British national formulary : BNF 76 (76th ed.). Pharmaceutical Press. 2018. pp. 247–248. ISBN 9780857113382.</ref> Specifically it is used during periods of breathing difficulty to prevent them from getting worse, rather than to prevent them from happening.<ref name="a10">[https://www.drugs.com/monograph/tiotropium.html "Tiotropium Bromide Monograph for Professionals".] Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 14 October 2018. Retrieved 31 January 2019.</ref> See also [https://en.wikipedia.org/wiki/Tiotropium_bromide Tiotropium bromide]. | Tiotropium bromide, sold under the brand name Spiriva among others, is a long-acting bronchodilator (LAMA: long acting muscarinic antagonist) used in the management of chronic obstructive pulmonary disease (COPD) and asthma.<ref name="a10">[https://www.drugs.com/monograph/tiotropium.html "Tiotropium Bromide Monograph for Professionals".] Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 14 October 2018. Retrieved 31 January 2019.</ref><ref name="a11">British national formulary : BNF 76 (76th ed.). Pharmaceutical Press. 2018. pp. 247–248. ISBN 9780857113382.</ref> Specifically it is used during periods of breathing difficulty to prevent them from getting worse, rather than to prevent them from happening.<ref name="a10">[https://www.drugs.com/monograph/tiotropium.html "Tiotropium Bromide Monograph for Professionals".] Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 14 October 2018. Retrieved 31 January 2019.</ref> See also [https://en.wikipedia.org/wiki/Tiotropium_bromide Tiotropium bromide]. | ||
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<scene name='10/1013887/Cv/3'>M3 muscarinic acetylcholine receptor bound to the antagonist tiotropium</scene> ([[4u14]]). | <scene name='10/1013887/Cv/3'>M3 muscarinic acetylcholine receptor bound to the antagonist tiotropium</scene> ([[4u14]]). | ||
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| + | <scene name='10/1013887/Binding_site/1'>Tiotropium binding site</scene>. | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
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References
- ↑ 1.0 1.1 "Tiotropium Bromide Monograph for Professionals". Drugs.com. American Society of Health-System Pharmacists. Archived from the original on 14 October 2018. Retrieved 31 January 2019.
- ↑ British national formulary : BNF 76 (76th ed.). Pharmaceutical Press. 2018. pp. 247–248. ISBN 9780857113382.
- ↑ Kato M, Komamura K, Kitakaze M. Tiotropium, a novel muscarinic M3 receptor antagonist, improved symptoms of chronic obstructive pulmonary disease complicated by chronic heart failure. Circ J. 2006 Dec;70(12):1658-60. PMID:17127817 doi:10.1253/circj.70.1658
