Amiodarone
From Proteopedia
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| - | <StructureSection load='' size='340' side='right' caption=' | + | <StructureSection load='' size='340' side='right' caption='Amiodarone' scene='10/1017435/Cv/1'> |
Amiodarone is an antiarrhythmic medication used to treat and prevent a number of types of cardiac dysrhythmias. This includes ventricular tachycardia (VT), ventricular fibrillation (VF), and wide complex tachycardia, as well as atrial fibrillation and paroxysmal supraventricular tachycardia.<ref name="a4">[https://www.drugs.com/monograph/amiodarone.html "Amiodarone Hydrochloride".] The American Society of Health-System Pharmacists. Archived from the original on 19 September 2016. Retrieved 22 August 2016</ref> See also [https://en.wikipedia.org/wiki/Amiodarone Amiodarone]. | Amiodarone is an antiarrhythmic medication used to treat and prevent a number of types of cardiac dysrhythmias. This includes ventricular tachycardia (VT), ventricular fibrillation (VF), and wide complex tachycardia, as well as atrial fibrillation and paroxysmal supraventricular tachycardia.<ref name="a4">[https://www.drugs.com/monograph/amiodarone.html "Amiodarone Hydrochloride".] The American Society of Health-System Pharmacists. Archived from the original on 19 September 2016. Retrieved 22 August 2016</ref> See also [https://en.wikipedia.org/wiki/Amiodarone Amiodarone]. | ||
| - | [[8e56]] | + | Amiodarone is categorized as a class III antiarrhythmic agent, and prolongs phase 3 of the cardiac action potential, the repolarization phase where there is normally decreased calcium permeability and increased potassium permeability. It has numerous other effects, however, including actions that are similar to those of antiarrhythmic classes Ia, II, and IV. |
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| + | Amiodarone is a blocker of [[Potassium Channel|voltage gated potassium]] (more exactly KCNH2) and [[Voltage-gated calcium channels|voltage gated calcium channels]] (more exactly CACNA2D2).<ref name="a50">[https://go.drugbank.com/drugs/DB01118 "Amiodarone".] Drugbank. Retrieved 28 May 2019.</ref> | ||
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| + | <scene name='10/1017435/Cv/2'>Voltage-dependent L-type calcium channel subunit alpha-1S with Amiodarone</scene> ([[8e56]]). | ||
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| + | <scene name='10/1017435/Cv/3'>Amiodarone binding site</scene>. | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
Current revision
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References
- ↑ "Amiodarone Hydrochloride". The American Society of Health-System Pharmacists. Archived from the original on 19 September 2016. Retrieved 22 August 2016
- ↑ "Amiodarone". Drugbank. Retrieved 28 May 2019.
