Duloxetine
From Proteopedia
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| - | <StructureSection load='' size='340' side='right' caption=' | + | <StructureSection load='' size='340' side='right' caption='Duloxetine' scene='97/975936/Cv/1'> |
Duloxetine, sold under the brand name Cymbalta among others, is a medication used to treat major depressive disorder, generalized anxiety disorder, fibromyalgia, neuropathic pain and central sensitization. See also [https://en.wikipedia.org/wiki/Duloxetine]. | Duloxetine, sold under the brand name Cymbalta among others, is a medication used to treat major depressive disorder, generalized anxiety disorder, fibromyalgia, neuropathic pain and central sensitization. See also [https://en.wikipedia.org/wiki/Duloxetine]. | ||
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In vitro binding studies using synaptosomal preparations isolated from rat cerebral cortex indicated that duloxetine was approximately 3 fold more potent at inhibiting serotonin uptake than norepinephrine uptake.<ref name="a64">PMID:28913467</ref> | In vitro binding studies using synaptosomal preparations isolated from rat cerebral cortex indicated that duloxetine was approximately 3 fold more potent at inhibiting serotonin uptake than norepinephrine uptake.<ref name="a64">PMID:28913467</ref> | ||
| - | <scene name='97/975936/Cv/2'>Sodium-dependent dopamine transporter in S-duloxetine bound form</scene> ([[6m38]]). | + | <scene name='97/975936/Cv/2'>Drosophila Sodium-dependent dopamine transporter in S-duloxetine bound form</scene> ([[6m38]]). |
<scene name='97/975936/Binding_site/1'>S-duloxetine binding site</scene>. | <scene name='97/975936/Binding_site/1'>S-duloxetine binding site</scene>. | ||
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References
- ↑ Stahl S (2013). Stahl's Essential Pharmacology (4th ed.). New York: Cambridge University Press. pp. 305, 308, 309.
- ↑ Stahl SM, Grady MM, Moret C, Briley M. SNRIs: their pharmacology, clinical efficacy, and tolerability in comparison with other classes of antidepressants. CNS Spectr. 2005 Sep;10(9):732-47. PMID:16142213 doi:10.1017/s1092852900019726
- ↑ Bymaster FP, Lee TC, Knadler MP, Detke MJ, Iyengar S. The dual transporter inhibitor duloxetine: a review of its preclinical pharmacology, pharmacokinetic profile, and clinical results in depression. Curr Pharm Des. 2005;11(12):1475-93. PMID:15892657 doi:10.2174/1381612053764805
- ↑ Onuţu AH. Duloxetine, an antidepressant with analgesic properties Rom J Anaesth Intensive Care. 2015 Oct;22(2):123-128 PMID:28913467
