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6hp9

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Current revision (11:35, 24 January 2024) (edit) (undo)
 
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<StructureSection load='6hp9' size='340' side='right'caption='[[6hp9]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
<StructureSection load='6hp9' size='340' side='right'caption='[[6hp9]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6hp9]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HP9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HP9 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6hp9]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HP9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HP9 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GKB:(2~{R})-~{N}-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-2-(pyrimidin-5-ylamino)-2,3-dihydro-1~{H}-indene-5-carboxamide'>GKB</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.96&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DDR1, CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GKB:(2~{R})-~{N}-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-2-(pyrimidin-5-ylamino)-2,3-dihydro-1~{H}-indene-5-carboxamide'>GKB</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6hp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hp9 OCA], [https://pdbe.org/6hp9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6hp9 RCSB], [https://www.ebi.ac.uk/pdbsum/6hp9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6hp9 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hp9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hp9 OCA], [http://pdbe.org/6hp9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hp9 RCSB], [http://www.ebi.ac.uk/pdbsum/6hp9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hp9 ProSAT]</span></td></tr>
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</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DDR1_HUMAN DDR1_HUMAN]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Receptor protein-tyrosine kinase]]
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[[Category: Arrowsmith CH]]
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[[Category: Arrowsmith, C H]]
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[[Category: Bountra C]]
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[[Category: Bountra, C]]
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[[Category: Bullock AN]]
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[[Category: Bullock, A N]]
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[[Category: Burgess-Brown NA]]
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[[Category: Burgess-Brown, N A]]
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[[Category: Edwards AM]]
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[[Category: Delft, F von]]
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[[Category: Fox AE]]
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[[Category: Edwards, A M]]
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[[Category: Kupinska K]]
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[[Category: Fox, A E]]
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[[Category: Pinkas DM]]
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[[Category: Kupinska, K]]
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[[Category: Von Delft F]]
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[[Category: Pinkas, D M]]
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[[Category: Structural genomic]]
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[[Category: Ddr1]]
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[[Category: Sgc]]
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[[Category: Transferase]]
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Current revision

Structure of the kinase domain of human DDR1 in complex with a 2-Amino-2,3-Dihydro-1H-Indene-5-Carboxamide-based inhibitor

PDB ID 6hp9

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