This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


6i0m

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:43, 24 January 2024) (edit) (undo)
 
(One intermediate revision not shown.)
Line 1: Line 1:
==Structure of human IMP dehydrogenase, isoform 2, bound to GDP==
==Structure of human IMP dehydrogenase, isoform 2, bound to GDP==
-
<StructureSection load='6i0m' size='340' side='right' caption='[[6i0m]], [[Resolution|resolution]] 2.57&Aring;' scene=''>
+
<StructureSection load='6i0m' size='340' side='right'caption='[[6i0m]], [[Resolution|resolution]] 2.57&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
-
<table><tr><td colspan='2'>[[6i0m]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I0M OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6I0M FirstGlance]. <br>
+
<table><tr><td colspan='2'>[[6i0m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I0M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6I0M FirstGlance]. <br>
-
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.567&#8491;</td></tr>
-
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/IMP_dehydrogenase IMP dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.205 1.1.1.205] </span></td></tr>
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=5GP:GUANOSINE-5-MONOPHOSPHATE'>5GP</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6i0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i0m OCA], [http://pdbe.org/6i0m PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6i0m RCSB], [http://www.ebi.ac.uk/pdbsum/6i0m PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6i0m ProSAT]</span></td></tr>
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6i0m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i0m OCA], [https://pdbe.org/6i0m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6i0m RCSB], [https://www.ebi.ac.uk/pdbsum/6i0m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6i0m ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
-
[[http://www.uniprot.org/uniprot/IMDH2_HUMAN IMDH2_HUMAN]] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.[HAMAP-Rule:MF_03156]
+
[https://www.uniprot.org/uniprot/IMDH2_HUMAN IMDH2_HUMAN] Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.[HAMAP-Rule:MF_03156]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 19: Line 19:
</div>
</div>
<div class="pdbe-citations 6i0m" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6i0m" style="background-color:#fffaf0;"></div>
 +
 +
==See Also==
 +
*[[Inosine monophosphate dehydrogenase 3D structures|Inosine monophosphate dehydrogenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
-
[[Category: IMP dehydrogenase]]
+
[[Category: Homo sapiens]]
-
[[Category: Buey, R M]]
+
[[Category: Large Structures]]
-
[[Category: Fernandez-Justel, D]]
+
[[Category: Buey RM]]
-
[[Category: Revuelta, J L]]
+
[[Category: Fernandez-Justel D]]
-
[[Category: Biosynthetic protein]]
+
[[Category: Revuelta JL]]
-
[[Category: De novo guanine nucleotide biosynthesis]]
+
-
[[Category: Oxidoreductase]]
+

Current revision

Structure of human IMP dehydrogenase, isoform 2, bound to GDP

PDB ID 6i0m

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/6i0m"
Personal tools