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6i6z

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<StructureSection load='6i6z' size='340' side='right'caption='[[6i6z]], [[Resolution|resolution]] 1.72&Aring;' scene=''>
<StructureSection load='6i6z' size='340' side='right'caption='[[6i6z]], [[Resolution|resolution]] 1.72&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6i6z]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I6Z OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6I6Z FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6i6z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4uef 4uef]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6I6Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6I6Z FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=TJE:(2S)-2-{[(S)-{(1R)-1-[(N-ACETYL-L-TYROSYL)AMINO]ETHYL}(HYDROXY)PHOSPHORYL]METHYL}-4-PHENYLBUTANOIC+ACID'>TJE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.72&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CPA1, CPA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TJE:(2S)-2-{[(S)-{(1R)-1-[(N-ACETYL-L-TYROSYL)AMINO]ETHYL}(HYDROXY)PHOSPHORYL]METHYL}-4-PHENYLBUTANOIC+ACID'>TJE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carboxypeptidase_A Carboxypeptidase A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.17.1 3.4.17.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6i6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i6z OCA], [https://pdbe.org/6i6z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6i6z RCSB], [https://www.ebi.ac.uk/pdbsum/6i6z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6i6z ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6i6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6i6z OCA], [http://pdbe.org/6i6z PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6i6z RCSB], [http://www.ebi.ac.uk/pdbsum/6i6z PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6i6z ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CBPA1_HUMAN CBPA1_HUMAN]] Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.<ref>PMID:8806703</ref>
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[https://www.uniprot.org/uniprot/CBPA1_HUMAN CBPA1_HUMAN] Carboxypeptidase that catalyzes the release of a C-terminal amino acid, but has little or no action with -Asp, -Glu, -Arg, -Lys or -Pro.<ref>PMID:8806703</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6i6z" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6i6z" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Carboxypeptidase 3D structures|Carboxypeptidase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Carboxypeptidase A]]
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[[Category: Homo sapiens]]
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[[Category: Human]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Gallego, P]]
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[[Category: Gallego P]]
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[[Category: Reverter, D]]
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[[Category: Reverter D]]
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[[Category: Hydrolase]]
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[[Category: Protease]]
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Current revision

Crystal structure of the human CARBOXYPEPTIDASE A1 in complex with the PHOSPHINIC INHIBITOR Acetyl-Tyr-Ala-Y(PO2CH2)-homoPhe-OH

PDB ID 6i6z

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