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6r63

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Current revision (12:16, 24 January 2024) (edit) (undo)
 
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<StructureSection load='6r63' size='340' side='right'caption='[[6r63]], [[Resolution|resolution]] 2.89&Aring;' scene=''>
<StructureSection load='6r63' size='340' side='right'caption='[[6r63]], [[Resolution|resolution]] 2.89&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6r63]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R63 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6R63 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6r63]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6R63 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6R63 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=JTB:4-chloranyl-2-(2~{H}-1,2,3-triazol-4-yl)phenol'>JTB</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.894&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IDO1, IDO, INDO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=JTB:4-chloranyl-2-(2~{H}-1,2,3-triazol-4-yl)phenol'>JTB</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Indoleamine_2,3-dioxygenase Indoleamine 2,3-dioxygenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.13.11.52 1.13.11.52] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6r63 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r63 OCA], [https://pdbe.org/6r63 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6r63 RCSB], [https://www.ebi.ac.uk/pdbsum/6r63 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6r63 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6r63 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6r63 OCA], [http://pdbe.org/6r63 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6r63 RCSB], [http://www.ebi.ac.uk/pdbsum/6r63 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6r63 ProSAT]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/I23O1_HUMAN I23O1_HUMAN]] Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen.<ref>PMID:17671174</ref>
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[https://www.uniprot.org/uniprot/I23O1_HUMAN I23O1_HUMAN] Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen.<ref>PMID:17671174</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6r63" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6r63" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Dioxygenase 3D structures|Dioxygenase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Indoleamine 2,3-dioxygenase]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Michielin, O]]
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[[Category: Michielin O]]
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[[Category: Pojer, F]]
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[[Category: Pojer F]]
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[[Category: Reynaud, A]]
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[[Category: Reynaud A]]
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[[Category: Roehrig, U F]]
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[[Category: Roehrig UF]]
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[[Category: Zoete, V]]
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[[Category: Zoete V]]
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[[Category: Dioxygenase]]
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[[Category: Heme-containing enzyme]]
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[[Category: Ido1 inhibitor]]
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[[Category: Oxidoreductase]]
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[[Category: Small-molecule inhibitor]]
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[[Category: Structure-based drug design]]
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[[Category: Triazole]]
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Current revision

Crystal structure of indoleamine 2,3-dioxygenase 1 (IDO1) in complex with ferric heme and MMG-0358

PDB ID 6r63

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