6rt8
From Proteopedia
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<StructureSection load='6rt8' size='340' side='right'caption='[[6rt8]], [[Resolution|resolution]] 2.19Å' scene=''> | <StructureSection load='6rt8' size='340' side='right'caption='[[6rt8]], [[Resolution|resolution]] 2.19Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6rt8]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RT8 OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[6rt8]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Catharanthus_roseus Catharanthus roseus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RT8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RT8 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KJE:18-carboxymethoxy-cleaviminium'>KJE</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.19Å</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KJE:18-carboxymethoxy-cleaviminium'>KJE</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rt8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rt8 OCA], [https://pdbe.org/6rt8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rt8 RCSB], [https://www.ebi.ac.uk/pdbsum/6rt8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rt8 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/CS_CATRO CS_CATRO] Component of iboga and aspidosperma monoterpenoid indole alkaloids (MIAs, e.g. tabersonine and catharanthine) biosynthesis pathway from 19E-geissoschizine. Catalyzes the conversion of O-acetylstemmadenine (OAS) to catharanthine.<ref>PMID:29511102</ref> <ref>PMID:29724909</ref> |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Catharanthus roseus]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Bussey | + | [[Category: Bussey K]] |
| - | [[Category: Caputi | + | [[Category: Caputi L]] |
| - | [[Category: | + | [[Category: Curcino Vieira IJ]] |
| - | [[Category: Farrow | + | [[Category: Farrow SC]] |
| - | [[Category: Franke | + | [[Category: Franke J]] |
| - | [[Category: Lawson | + | [[Category: Lawson DM]] |
| - | [[Category: | + | [[Category: O'Connor SE]] |
| - | [[Category: | + | [[Category: Stevenson CEM]] |
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Current revision
Structure of catharanthine synthase - an alpha-beta hydrolase from Catharanthus roseus with a cleaviminium intermediate bound
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