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6rt8

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Current revision (12:27, 24 January 2024) (edit) (undo)
 
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<StructureSection load='6rt8' size='340' side='right'caption='[[6rt8]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
<StructureSection load='6rt8' size='340' side='right'caption='[[6rt8]], [[Resolution|resolution]] 2.19&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6rt8]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Catro Catro]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RT8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6RT8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6rt8]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Catharanthus_roseus Catharanthus roseus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6RT8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6RT8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=KJE:18-carboxymethoxy-cleaviminium'>KJE</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.19&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CS, HL1, Caros025416 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4058 CATRO])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=KJE:18-carboxymethoxy-cleaviminium'>KJE</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6rt8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rt8 OCA], [http://pdbe.org/6rt8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6rt8 RCSB], [http://www.ebi.ac.uk/pdbsum/6rt8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6rt8 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6rt8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6rt8 OCA], [https://pdbe.org/6rt8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6rt8 RCSB], [https://www.ebi.ac.uk/pdbsum/6rt8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6rt8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CS_CATRO CS_CATRO]] Component of iboga and aspidosperma monoterpenoid indole alkaloids (MIAs, e.g. tabersonine and catharanthine) biosynthesis pathway from 19E-geissoschizine. Catalyzes the conversion of O-acetylstemmadenine (OAS) to catharanthine.<ref>PMID:29511102</ref> <ref>PMID:29724909</ref>
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[https://www.uniprot.org/uniprot/CS_CATRO CS_CATRO] Component of iboga and aspidosperma monoterpenoid indole alkaloids (MIAs, e.g. tabersonine and catharanthine) biosynthesis pathway from 19E-geissoschizine. Catalyzes the conversion of O-acetylstemmadenine (OAS) to catharanthine.<ref>PMID:29511102</ref> <ref>PMID:29724909</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Catro]]
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[[Category: Catharanthus roseus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bussey, K]]
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[[Category: Bussey K]]
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[[Category: Caputi, L]]
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[[Category: Caputi L]]
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[[Category: Connor, S E.O]]
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[[Category: Curcino Vieira IJ]]
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[[Category: Farrow, S C]]
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[[Category: Farrow SC]]
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[[Category: Franke, J]]
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[[Category: Franke J]]
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[[Category: Lawson, D M]]
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[[Category: Lawson DM]]
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[[Category: Stevenson, C E.M]]
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[[Category: O'Connor SE]]
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[[Category: Vieira, I J.Curcino]]
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[[Category: Stevenson CEM]]
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[[Category: Alkaloid]]
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[[Category: Alpha/beta hydrolase fold]]
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[[Category: Biosynthesis]]
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[[Category: Catharanthine]]
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[[Category: Hydrolase]]
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[[Category: Natural product]]
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Current revision

Structure of catharanthine synthase - an alpha-beta hydrolase from Catharanthus roseus with a cleaviminium intermediate bound

PDB ID 6rt8

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