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6s0i
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of Escherichia coli Glyoxalase II with L-Tartrate in the active site== | |
| + | <StructureSection load='6s0i' size='340' side='right'caption='[[6s0i]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[6s0i]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S0I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6S0I FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.803Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6s0i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s0i OCA], [https://pdbe.org/6s0i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6s0i RCSB], [https://www.ebi.ac.uk/pdbsum/6s0i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6s0i ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/GLO2_ECOLI GLO2_ECOLI] Type II glyoxalase that catalyzes the hydrolysis of (R)-S-lactoylglutathione to (R)-lactate and glutathione (PubMed:25670698, PubMed:17196158). Is more efficient than the isozyme GloC, and plays a major contribution to methylglyoxal (MG) detoxification in E.coli (PubMed:25670698). The two isoenzymes have additive effects and ensure maximal MG degradation (PubMed:25670698).<ref>PMID:17196158</ref> <ref>PMID:25670698</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Glyoxalase 3D structures|Glyoxalase 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Escherichia coli K-12]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: McDonough MA]] | ||
| + | [[Category: Schofield CJ]] | ||
| + | [[Category: Skorupskaite A]] | ||
Current revision
Crystal structure of Escherichia coli Glyoxalase II with L-Tartrate in the active site
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