6sm5
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 6sm5 is ON HOLD Authors: Mann, G., Hantschel, O. Description: MbC/SHP1-C-SH2 complex Category: Unreleased Structures Category: Hantschel, O...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==MbC/SHP1-C-SH2 complex== | |
| - | + | <StructureSection load='6sm5' size='340' side='right'caption='[[6sm5]], [[Resolution|resolution]] 2.75Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[6sm5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6SM5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6SM5 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6sm5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6sm5 OCA], [https://pdbe.org/6sm5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6sm5 RCSB], [https://www.ebi.ac.uk/pdbsum/6sm5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6sm5 ProSAT]</span></td></tr> |
| - | [[Category: Hantschel | + | </table> |
| - | [[Category: Mann | + | == Function == |
| + | [https://www.uniprot.org/uniprot/PTN6_HUMAN PTN6_HUMAN] Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.<ref>PMID:11266449</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Hantschel O]] | ||
| + | [[Category: Mann G]] | ||
Current revision
MbC/SHP1-C-SH2 complex
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