6tav

<StructureSection load='6tav' size='340' side='right'caption='[[6tav]], [[Resolution|resolution]] 4.20&Aring;' scene=''>

<table><tr><td colspan='2'>[[6tav]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=4acq 4acq]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TAV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TAV FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.2&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tav FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tav OCA], [https://pdbe.org/6tav PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tav RCSB], [https://www.ebi.ac.uk/pdbsum/6tav PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tav ProSAT]</span></td></tr>

== Function ==

[https://www.uniprot.org/uniprot/A2MG_HUMAN A2MG_HUMAN] Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

[[Category: Homo sapiens]]