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6tod

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<StructureSection load='6tod' size='340' side='right'caption='[[6tod]], [[Resolution|resolution]] 2.11&Aring;' scene=''>
<StructureSection load='6tod' size='340' side='right'caption='[[6tod]], [[Resolution|resolution]] 2.11&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6tod]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TOD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6TOD FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6tod]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TOD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TOD FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=7MA:N-ethyl-2-[(6-methoxypyridin-3-yl)-(2-methylphenyl)sulfonyl-amino]-N-(pyridin-3-ylmethyl)ethanamide'>7MA</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGW:(1R)-2-{[(S)-{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(HEXADECANOYLOXY)METHYL]ETHYL+(9Z)-OCTADEC-9-ENOATE'>PGW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SOG:2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL'>SOG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.11&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[6to7|6to7]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7MA:N-ethyl-2-[(6-methoxypyridin-3-yl)-(2-methylphenyl)sulfonyl-amino]-N-(pyridin-3-ylmethyl)ethanamide'>7MA</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGW:(1R)-2-{[(S)-{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(HEXADECANOYLOXY)METHYL]ETHYL+(9Z)-OCTADEC-9-ENOATE'>PGW</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=SOG:2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL'>SOG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6tod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tod OCA], [http://pdbe.org/6tod PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6tod RCSB], [http://www.ebi.ac.uk/pdbsum/6tod PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6tod ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tod FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tod OCA], [https://pdbe.org/6tod PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tod RCSB], [https://www.ebi.ac.uk/pdbsum/6tod PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tod ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/OX1R_HUMAN OX1R_HUMAN]] Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade (By similarity).
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[https://www.uniprot.org/uniprot/OX1R_HUMAN OX1R_HUMAN] Moderately selective excitatory receptor for orexin-A and, with a lower affinity, for orexin-B neuropeptide. Seems to be exclusively coupled to the G(q) subclass of heteromeric G proteins, which activates the phospholipase C mediated signaling cascade (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6tod" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6tod" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Orexin and Orexin receptor|Orexin and Orexin receptor]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Ali, A]]
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[[Category: Ali A]]
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[[Category: Bennett, K A]]
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[[Category: Bennett KA]]
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[[Category: Brown, J D]]
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[[Category: Brown JD]]
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[[Category: Bucknell, S J]]
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[[Category: Bucknell SJ]]
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[[Category: Christopher, J A]]
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[[Category: Christopher JA]]
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[[Category: Congreve, M]]
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[[Category: Congreve M]]
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[[Category: Cooke, R M]]
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[[Category: Cooke RM]]
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[[Category: Cseke, G]]
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[[Category: Cseke G]]
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[[Category: Dore, A S]]
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[[Category: Dore AS]]
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[[Category: Errey, J C]]
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[[Category: Errey JC]]
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[[Category: Graaf, C de]]
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[[Category: Jazayeri A]]
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[[Category: Jazayeri, A]]
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[[Category: Marshall FH]]
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[[Category: Marshall, F H]]
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[[Category: Mason JS]]
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[[Category: Mason, J S]]
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[[Category: Mould R]]
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[[Category: Mould, R]]
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[[Category: Patel JC]]
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[[Category: Patel, J C]]
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[[Category: Rappas M]]
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[[Category: Rappas, M]]
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[[Category: Tehan BG]]
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[[Category: Tehan, B G]]
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[[Category: Weir M]]
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[[Category: Weir, M]]
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[[Category: De Graaf C]]
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[[Category: Gpcr]]
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[[Category: Membrane protein]]
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Current revision

Crystal structure of the Orexin-1 receptor in complex with EMPA

PDB ID 6tod

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