This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
6tpn
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
<StructureSection load='6tpn' size='340' side='right'caption='[[6tpn]], [[Resolution|resolution]] 2.61Å' scene=''> | <StructureSection load='6tpn' size='340' side='right'caption='[[6tpn]], [[Resolution|resolution]] 2.61Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6tpn]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[6tpn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Pyrococcus_abyssi_GE5 Pyrococcus abyssi GE5]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TPN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TPN FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=NU8:2-(5,6-dimethoxypyridin-3-yl)-1,1-bis(oxidanylidene)-4-[[2,4,6-tris(fluoranyl)phenyl]methyl]pyrido[2,3-e][1,2,4]thiadiazin-3-one'>NU8</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.608Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NO3:NITRATE+ION'>NO3</scene>, <scene name='pdbligand=NU8:2-(5,6-dimethoxypyridin-3-yl)-1,1-bis(oxidanylidene)-4-[[2,4,6-tris(fluoranyl)phenyl]methyl]pyrido[2,3-e][1,2,4]thiadiazin-3-one'>NU8</scene>, <scene name='pdbligand=OLA:OLEIC+ACID'>OLA</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=YCM:S-(2-AMINO-2-OXOETHYL)-L-CYSTEINE'>YCM</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tpn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tpn OCA], [https://pdbe.org/6tpn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tpn RCSB], [https://www.ebi.ac.uk/pdbsum/6tpn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tpn ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[ | + | [https://www.uniprot.org/uniprot/Q9V2J8_PYRAB Q9V2J8_PYRAB] [https://www.uniprot.org/uniprot/OX2R_HUMAN OX2R_HUMAN] Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 20: | Line 19: | ||
</div> | </div> | ||
<div class="pdbe-citations 6tpn" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 6tpn" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Orexin and Orexin receptor|Orexin and Orexin receptor]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Ali | + | [[Category: Pyrococcus abyssi GE5]] |
| - | [[Category: Bennett | + | [[Category: Ali A]] |
| - | [[Category: Brown | + | [[Category: Bennett KA]] |
| - | [[Category: Bucknell | + | [[Category: Brown JD]] |
| - | [[Category: Christopher | + | [[Category: Bucknell SJ]] |
| - | [[Category: Congreve | + | [[Category: Christopher JA]] |
| - | [[Category: Cooke | + | [[Category: Congreve M]] |
| - | [[Category: Cseke | + | [[Category: Cooke RM]] |
| - | [[Category: Dore | + | [[Category: Cseke G]] |
| - | [[Category: Errey | + | [[Category: Dore AS]] |
| - | + | [[Category: Errey JC]] | |
| - | [[Category: Jazayeri | + | [[Category: Jazayeri A]] |
| - | [[Category: Marshall | + | [[Category: Marshall FH]] |
| - | [[Category: Mason | + | [[Category: Mason JS]] |
| - | [[Category: Mould | + | [[Category: Mould R]] |
| - | [[Category: Patel | + | [[Category: Patel JC]] |
| - | [[Category: Rappas | + | [[Category: Rappas M]] |
| - | [[Category: Tehan | + | [[Category: Tehan BG]] |
| - | [[Category: Weir | + | [[Category: Weir M]] |
| - | [[Category: | + | [[Category: De Graaf C]] |
| - | + | ||
Current revision
Crystal structure of the Orexin-2 receptor in complex with HTL6641 at 2.61 A resolution
| |||||||||||
Categories: Homo sapiens | Large Structures | Pyrococcus abyssi GE5 | Ali A | Bennett KA | Brown JD | Bucknell SJ | Christopher JA | Congreve M | Cooke RM | Cseke G | Dore AS | Errey JC | Jazayeri A | Marshall FH | Mason JS | Mould R | Patel JC | Rappas M | Tehan BG | Weir M | De Graaf C
