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6trr

From Proteopedia

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Current revision (13:07, 24 January 2024) (edit) (undo)
 
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<StructureSection load='6trr' size='340' side='right'caption='[[6trr]], [[Resolution|resolution]] 2.12&Aring;' scene=''>
<StructureSection load='6trr' size='340' side='right'caption='[[6trr]], [[Resolution|resolution]] 2.12&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6trr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Tanapox_virus_strain_davis Tanapox virus strain davis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TRR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TRR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6trr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Yaba-like_disease_virus Yaba-like disease virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TRR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TRR FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1200736&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">16L ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=132475 Tanapox virus strain Davis])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6trr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6trr OCA], [https://pdbe.org/6trr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6trr RCSB], [https://www.ebi.ac.uk/pdbsum/6trr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6trr ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6trr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6trr OCA], [https://pdbe.org/6trr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6trr RCSB], [https://www.ebi.ac.uk/pdbsum/6trr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6trr ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/BAX_HUMAN BAX_HUMAN]] Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.<ref>PMID:8358790</ref> <ref>PMID:10772918</ref> <ref>PMID:8521816</ref> <ref>PMID:16113678</ref> <ref>PMID:18948948</ref> <ref>PMID:21199865</ref>
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[https://www.uniprot.org/uniprot/Q9DHU6_YLDV Q9DHU6_YLDV]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Tanapox virus strain davis]]
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[[Category: Yaba-like disease virus]]
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[[Category: Hinds, M G]]
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[[Category: Hinds MG]]
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[[Category: Kvansakul, M]]
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[[Category: Kvansakul M]]
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[[Category: Suraweera, C D]]
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[[Category: Suraweera CD]]
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[[Category: Apoptosis]]
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[[Category: Bcl-2]]
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[[Category: Pox virus]]
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Current revision

Structural insight into tanapoxvirus mediated inhibition of apoptosis

PDB ID 6trr

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