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6yhw

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Current revision (13:27, 24 January 2024) (edit) (undo)
 
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<StructureSection load='6yhw' size='340' side='right'caption='[[6yhw]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
<StructureSection load='6yhw' size='340' side='right'caption='[[6yhw]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6yhw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5ab1 5ab1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YHW OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=6YHW FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6yhw]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=5ab1 5ab1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YHW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YHW FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=HP6:HEPTANE'>HP6</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=TA5:2H-1,2,3-TRIAZOL-4-YLMETHANOL'>TA5</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.962&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">fimH, fimH_1, fimH_2, fimH_3, sfaH_2, A6581_19835, ACN81_00940, AKG99_10920, AM446_24165, AM464_16260, AUQ13_11280, AWG78_008695, B6V57_25500, B9M99_24715, B9T59_08965, BON65_08035, BON69_13145, BON76_10045, BON87_19590, BvCms12BK_05011, BvCms2454_04206, C2U48_10910, C5P44_07835, C6B13_05760, CR538_22045, CRX46_08755, D2188_19245, D9G11_20470, D9H70_11375, D9I97_23340, D9J60_03345, DJ503_16470, DNQ45_27015, DS732_03965, DU321_25405, DXT73_23425, E0L12_19135, EC3234A_192c00060, ECONIH1_25860, ECTO6_04155, EIA21_01475, ELV08_23920, EQ830_16720, ERS085383_04267, F0312_06085, F1E19_12715, FNJ69_21090, FNJ83_00985, FV293_11400, FY127_19655, MS6198_50840, MS8345_04977, NCTC10090_02366, NCTC8450_00821, NCTC9045_05036, SAMEA3472056_01232, YDC107_3079 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLC:ALPHA-D-GLUCOSE'>GLC</scene>, <scene name='pdbligand=HP6:HEPTANE'>HP6</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=PRD_900012:beta-cyclodextrin'>PRD_900012</scene>, <scene name='pdbligand=TA5:2H-1,2,3-TRIAZOL-4-YLMETHANOL'>TA5</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=6yhw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yhw OCA], [http://pdbe.org/6yhw PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6yhw RCSB], [http://www.ebi.ac.uk/pdbsum/6yhw PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6yhw ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6yhw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yhw OCA], [https://pdbe.org/6yhw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6yhw RCSB], [https://www.ebi.ac.uk/pdbsum/6yhw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6yhw ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FIMH_ECOLI FIMH_ECOLI] Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Adhesin responsible for the binding to D-mannose. It is laterally positioned at intervals in the structure of the type 1 fimbriae. In order to integrate FimH in the fimbriae FimF and FimG are needed.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Bouckaert, J]]
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[[Category: Bouckaert J]]
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[[Category: Ruyck, J de]]
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[[Category: De Ruyck J]]
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[[Category: Beta-cyclodextrin host-guest interactions inhibitor design]]
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[[Category: Cell adhesion]]
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Current revision

Co-crystals in the P212121 space group, of a beta-cyclodextrin spacered by triazole heptyl from alpha-D-mannose, with FimH lectin at 2.00 A resolution.

PDB ID 6yhw

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OCA

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