6z1c

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<StructureSection load='6z1c' size='340' side='right'caption='[[6z1c]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
<StructureSection load='6z1c' size='340' side='right'caption='[[6z1c]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6z1c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arath Arath]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z1C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Z1C FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6z1c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6Z1C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6Z1C FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7EY:3-[5-(4-METHYLPHENYL)THIENO[2,3-D]PYRIMIDIN-4-YL]SULFANYLPROPANOIC+ACID'>7EY</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[6xx6|6xx6]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7EY:3-[5-(4-METHYLPHENYL)THIENO[2,3-D]PYRIMIDIN-4-YL]SULFANYLPROPANOIC+ACID'>7EY</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CKA1, At5g67380, K8K14.10 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=3702 ARATH])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z1c OCA], [https://pdbe.org/6z1c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z1c RCSB], [https://www.ebi.ac.uk/pdbsum/6z1c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z1c ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6z1c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6z1c OCA], [https://pdbe.org/6z1c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6z1c RCSB], [https://www.ebi.ac.uk/pdbsum/6z1c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6z1c ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/CSK21_ARATH CSK21_ARATH]] Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates casein in vitro (PubMed:7678767). The alpha chain contains the catalytic site. The tetrameric holoenzyme CK2, composed of two alpha and two beta subunits, phosphorylates the transcription factor GBFl, resulting in stimulation of its DNA binding activity (PubMed:7696877). CK2 phosphorylates the transcription factor PIF1 after an exposure to light, resulting in a proteasome-dependent degradation of PIF1 and promotion of photomorphogenesis (PubMed:21330376). CK2 phosphorylates translation initiation factors. May participate in the regulation of the initiation of translation (PubMed:19509278, PubMed:19509420). Acts as circadian clock component that maintains the correct period length through phosphorylation of CCA1 (PubMed:21900482). Required for the maintenance and control of genomic stability and chromatin structure (PubMed:22487192). May act as an ectokinase that phosphorylates several extracellular proteins.<ref>PMID:19509278</ref> <ref>PMID:19509420</ref> <ref>PMID:21330376</ref> <ref>PMID:21900482</ref> <ref>PMID:22487192</ref> <ref>PMID:7678767</ref> <ref>PMID:7696877</ref>
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[https://www.uniprot.org/uniprot/CSK21_ARATH CSK21_ARATH] Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Phosphorylates casein in vitro (PubMed:7678767). The alpha chain contains the catalytic site. The tetrameric holoenzyme CK2, composed of two alpha and two beta subunits, phosphorylates the transcription factor GBFl, resulting in stimulation of its DNA binding activity (PubMed:7696877). CK2 phosphorylates the transcription factor PIF1 after an exposure to light, resulting in a proteasome-dependent degradation of PIF1 and promotion of photomorphogenesis (PubMed:21330376). CK2 phosphorylates translation initiation factors. May participate in the regulation of the initiation of translation (PubMed:19509278, PubMed:19509420). Acts as circadian clock component that maintains the correct period length through phosphorylation of CCA1 (PubMed:21900482). Required for the maintenance and control of genomic stability and chromatin structure (PubMed:22487192). May act as an ectokinase that phosphorylates several extracellular proteins.<ref>PMID:19509278</ref> <ref>PMID:19509420</ref> <ref>PMID:21330376</ref> <ref>PMID:21900482</ref> <ref>PMID:22487192</ref> <ref>PMID:7678767</ref> <ref>PMID:7696877</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6z1c" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6z1c" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Casein kinase 3D structures|Casein kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Arath]]
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[[Category: Arabidopsis thaliana]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Non-specific serine/threonine protein kinase]]
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[[Category: De Veylder L]]
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[[Category: Demulder, M]]
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[[Category: Demulder M]]
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[[Category: Loris, R]]
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[[Category: Loris R]]
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[[Category: Veylder, L De]]
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[[Category: Cell cycle]]
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[[Category: Inhibitor]]
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[[Category: Kinase]]
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[[Category: Plant protein]]
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Current revision

Crystal structure of Arabidopsis thaliana CK2-alpha-1 in complex with TTP-22

PDB ID 6z1c

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