5q07

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(New page: '''Unreleased structure''' The entry 5q07 is ON HOLD Authors: Yang, Huanwang Description: Ligand binding to FRUCTOSE-1,6-BISPHOSPHATASE Category: Unreleased Structures [[Category: ...)
Current revision (14:27, 24 January 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 5q07 is ON HOLD
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==Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(4-bromo-6-morpholin-4-ylpyridin-2-yl)-3-[5-(2-methoxyethyl)-4-methylthiophen-2-yl]sulfonylurea==
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<StructureSection load='5q07' size='340' side='right'caption='[[5q07]], [[Resolution|resolution]] 2.42&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5q07]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5Q07 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5Q07 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.424&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=95Y:N-{[4-bromo-6-(morpholin-4-yl)pyridin-2-yl]carbamoyl}-5-(2-methoxyethyl)-4-methylthiophene-2-sulfonamide'>95Y</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5q07 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5q07 OCA], [https://pdbe.org/5q07 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5q07 RCSB], [https://www.ebi.ac.uk/pdbsum/5q07 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5q07 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/F16P1_HUMAN F16P1_HUMAN] Defects in FBP1 are the cause of fructose-1,6-bisphosphatase deficiency (FBPD) [MIM:[https://omim.org/entry/229700 229700]. FBPD is inherited as an autosomal recessive disorder mainly in the liver and causes life-threatening episodes of hypoglycemia and metabolic acidosis (lactacidemia) in newborn infants or young children.<ref>PMID:9382095</ref> <ref>PMID:12126934</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/F16P1_HUMAN F16P1_HUMAN]
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Authors: Yang, Huanwang
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==See Also==
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*[[Fructose-1%2C6-bisphosphatase 3D structures|Fructose-1%2C6-bisphosphatase 3D structures]]
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Description: Ligand binding to FRUCTOSE-1,6-BISPHOSPHATASE
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Yang, Huanwang]]
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Alker A]]
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[[Category: Banner D]]
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[[Category: Benz J]]
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[[Category: Burley SK]]
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[[Category: Joseph C]]
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[[Category: Kuhn B]]
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[[Category: Rudolph MG]]
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[[Category: Ruf A]]
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[[Category: Shao C]]
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[[Category: Tetaz T]]
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[[Category: Yang H]]

Current revision

Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(4-bromo-6-morpholin-4-ylpyridin-2-yl)-3-[5-(2-methoxyethyl)-4-methylthiophen-2-yl]sulfonylurea

PDB ID 5q07

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OCA

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