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8c7m
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Interleukin 12 receptor subunit beta-1 Fn domains in complex with antagonistic FAb fragment.== | |
| - | + | <StructureSection load='8c7m' size='340' side='right'caption='[[8c7m]], [[Resolution|resolution]] 2.56Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8c7m]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Homo_sapiens_x_Mus_musculus_hybrid_cell_line Homo sapiens x Mus musculus hybrid cell line]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8C7M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8C7M FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.56Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8c7m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8c7m OCA], [https://pdbe.org/8c7m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8c7m RCSB], [https://www.ebi.ac.uk/pdbsum/8c7m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8c7m ProSAT]</span></td></tr> |
| - | [[Category: Bloch | + | </table> |
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/I12R1_HUMAN I12R1_HUMAN] Primary biliary cholangitis;Mendelian susceptibility to mycobacterial diseases due to complete IL12RB1 deficiency. The disease is caused by variants affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/I12R1_HUMAN I12R1_HUMAN] Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.<ref>PMID:12023369</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Homo sapiens x Mus musculus hybrid cell line]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bloch Y]] | ||
| + | [[Category: Savvides SN]] | ||
Current revision
Interleukin 12 receptor subunit beta-1 Fn domains in complex with antagonistic FAb fragment.
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