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8c8h
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Cryo EM structure of the vaccinia complete RNA polymerase complex lacking the capping enzyme== | |
| - | + | <StructureSection load='8c8h' size='340' side='right'caption='[[8c8h]], [[Resolution|resolution]] 3.84Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8c8h]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Vaccinia_virus_GLV-1h68 Vaccinia virus GLV-1h68]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8C8H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8C8H FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.84Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8c8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8c8h OCA], [https://pdbe.org/8c8h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8c8h RCSB], [https://www.ebi.ac.uk/pdbsum/8c8h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8c8h ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RP22_VACCW RP22_VACCW] Part of the DNA-dependent RNA polymerase which catalyzes the transcription of viral DNA into RNA using the four ribonucleoside triphosphates as substrates (PubMed:31835031). Responsible for the transcription of early, intermediate and late genes. DNA-dependent RNA polymerase associates with the early transcription factor (ETF), itself composed of OPG118 and OPG133, thereby allowing the early genes transcription. Late transcription, and probably also intermediate transcription, require newly synthesized RNA polymerase.<ref>PMID:19759131</ref> <ref>PMID:31835031</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Vaccinia virus GLV-1h68]] | ||
| + | [[Category: Bartuli J]] | ||
| + | [[Category: Fischer U]] | ||
| + | [[Category: Grimm G]] | ||
Current revision
Cryo EM structure of the vaccinia complete RNA polymerase complex lacking the capping enzyme
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