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8osb

From Proteopedia

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Current revision (11:43, 1 February 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8osb is ON HOLD until Paper Publication
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==TWIST1-TCF4-ALX4 complex on specific DNA==
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<StructureSection load='8osb' size='340' side='right'caption='[[8osb]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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Authors: Morgunova, E., Kim, S., Popov, A., Wysocka, J., Taipale, J.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8osb]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8OSB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8OSB FirstGlance]. <br>
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Description: TWIST1-TCF4-ALX4 complex on specific DNA
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8osb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8osb OCA], [https://pdbe.org/8osb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8osb RCSB], [https://www.ebi.ac.uk/pdbsum/8osb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8osb ProSAT]</span></td></tr>
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[[Category: Taipale, J]]
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</table>
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[[Category: Kim, S]]
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== Disease ==
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[[Category: Popov, A]]
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[https://www.uniprot.org/uniprot/ITF2_HUMAN ITF2_HUMAN] Autosomal dominant non-syndromic intellectual disability;Fuchs endothelial corneal dystrophy;Pitt-Hopkins syndrome;Schizophrenia;Primary sclerosing cholangitis. The disease is caused by mutations affecting the gene represented in this entry.
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[[Category: Morgunova, E]]
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== Function ==
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[[Category: Wysocka, J]]
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[https://www.uniprot.org/uniprot/ITF2_HUMAN ITF2_HUMAN] Transcription factor that binds to the immunoglobulin enchancer Mu-E5/KE5-motif. Involved in the initiation of neuronal differentiation. Activates transcription by binding to the E box (5'-CANNTG-3'). Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'.
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Kim S]]
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[[Category: Morgunova E]]
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[[Category: Popov A]]
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[[Category: Taipale J]]
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[[Category: Wysocka J]]

Current revision

TWIST1-TCF4-ALX4 complex on specific DNA

PDB ID 8osb

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