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7a0d
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The Crystal Structure of Bovine Thrombin in complex with Hirudin (C16U/C28U) at 1.6 Angstroms Resolution== |
| + | <StructureSection load='7a0d' size='340' side='right'caption='[[7a0d]], [[Resolution|resolution]] 1.60Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[7a0d]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus] and [https://en.wikipedia.org/wiki/Hirudo_medicinalis Hirudo medicinalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7A0D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7A0D FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7a0d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7a0d OCA], [https://pdbe.org/7a0d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7a0d RCSB], [https://www.ebi.ac.uk/pdbsum/7a0d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7a0d ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/THRB_BOVIN THRB_BOVIN] Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). | ||
| - | + | ==See Also== | |
| - | + | *[[Hirudin 3D structures|Hirudin 3D structures]] | |
| - | + | *[[Thrombin 3D Structures|Thrombin 3D Structures]] | |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Bos taurus]] |
| - | [[Category: | + | [[Category: Hirudo medicinalis]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Hidmi T]] |
| - | [[Category: | + | [[Category: Khouri L]] |
| - | [[Category: | + | [[Category: Lansky S]] |
| + | [[Category: Metanis N]] | ||
| + | [[Category: Mousa R]] | ||
| + | [[Category: Pomyalov S]] | ||
| + | [[Category: Shoham G]] | ||
Current revision
The Crystal Structure of Bovine Thrombin in complex with Hirudin (C16U/C28U) at 1.6 Angstroms Resolution
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Categories: Bos taurus | Hirudo medicinalis | Large Structures | Hidmi T | Khouri L | Lansky S | Metanis N | Mousa R | Pomyalov S | Shoham G
