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7o4d

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'''Unreleased structure'''
 
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The entry 7o4d is ON HOLD until Paper Publication
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==QR2 inhibitor from a novel sulfanamide series to tackle age related oxidative stress and cognitive decline==
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<StructureSection load='7o4d' size='340' side='right'caption='[[7o4d]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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Authors: Gould, N.L., Scherer, G.R., Carvalh, S., Shurrush, K., Edry, E., Elkobi, A., David, O., Dym, O., Albeck, S., Peleg, Y., Germain, N., Babaev, I., Sharir, H., Lefker, B., Subramanyam, C., Barr, H., Rosenblum, K.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[7o4d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7O4D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7O4D FirstGlance]. <br>
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Description: QR2 inhibitor from a novel sulfanamide series to tackle age related oxidative stress and cognitive decline
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.249&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=V1Z:8-methyl-2-(4-methyl-3-piperazin-1-ylsulfonyl-phenyl)imidazo[1,2-a]pyridine'>V1Z</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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[[Category: Germain, N]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7o4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7o4d OCA], [https://pdbe.org/7o4d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7o4d RCSB], [https://www.ebi.ac.uk/pdbsum/7o4d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7o4d ProSAT]</span></td></tr>
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[[Category: Subramanyam, C]]
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</table>
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[[Category: Carvalh, S]]
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== Function ==
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[[Category: Shurrush, K]]
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[https://www.uniprot.org/uniprot/NQO2_HUMAN NQO2_HUMAN] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.<ref>PMID:18254726</ref>
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[[Category: Albeck, S]]
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== References ==
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[[Category: Rosenblum, K]]
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<references/>
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[[Category: Lefker, B]]
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__TOC__
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[[Category: Babaev, I]]
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</StructureSection>
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[[Category: Peleg, Y]]
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[[Category: Homo sapiens]]
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[[Category: David, O]]
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[[Category: Large Structures]]
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[[Category: Elkobi, A]]
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[[Category: Albeck S]]
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[[Category: Sharir, H]]
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[[Category: Babaev I]]
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[[Category: Edry, E]]
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[[Category: Barr H]]
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[[Category: Barr, H]]
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[[Category: Carvalh S]]
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[[Category: Scherer, G.R]]
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[[Category: David O]]
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[[Category: Dym, O]]
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[[Category: Dym O]]
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[[Category: Gould, N.L]]
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[[Category: Edry E]]
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[[Category: Elkobi A]]
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[[Category: Germain N]]
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[[Category: Gould NL]]
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[[Category: Lefker B]]
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[[Category: Peleg Y]]
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[[Category: Rosenblum K]]
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[[Category: Scherer GR]]
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[[Category: Sharir H]]
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[[Category: Shurrush K]]
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[[Category: Subramanyam C]]

Current revision

QR2 inhibitor from a novel sulfanamide series to tackle age related oxidative stress and cognitive decline

PDB ID 7o4d

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