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7o69

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Current revision (12:45, 1 February 2024) (edit) (undo)
 
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<StructureSection load='7o69' size='340' side='right'caption='[[7o69]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
<StructureSection load='7o69' size='340' side='right'caption='[[7o69]], [[Resolution|resolution]] 1.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7o69]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7O69 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7O69 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7o69]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7O69 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7O69 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEO:HYDROGEN+PEROXIDE'>PEO</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.35&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[7o63|7o63]], [[7o64|7o64]], [[7o65|7o65]], [[7o66|7o66]], [[7o67|7o67]], [[7o68|7o68]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEO:HYDROGEN+PEROXIDE'>PEO</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Ferroxidase Ferroxidase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.16.3.1 1.16.3.1] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7o69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7o69 OCA], [https://pdbe.org/7o69 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7o69 RCSB], [https://www.ebi.ac.uk/pdbsum/7o69 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7o69 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7o69 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7o69 OCA], [https://pdbe.org/7o69 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7o69 RCSB], [https://www.ebi.ac.uk/pdbsum/7o69 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7o69 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/FTMT_HUMAN FTMT_HUMAN]] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.<ref>PMID:11323407</ref> <ref>PMID:15201052</ref>
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[https://www.uniprot.org/uniprot/FTMT_HUMAN FTMT_HUMAN] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation.<ref>PMID:11323407</ref> <ref>PMID:15201052</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 7o69" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 7o69" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Ferritin 3D structures|Ferritin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ferroxidase]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Ciambellotti, S]]
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[[Category: Ciambellotti S]]
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[[Category: Mangani, S]]
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[[Category: Mangani S]]
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[[Category: Pozzi, C]]
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[[Category: Pozzi C]]
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[[Category: Tassone, G]]
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[[Category: Tassone G]]
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[[Category: Turano, P]]
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[[Category: Turano P]]
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[[Category: Ferroxidase site]]
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[[Category: Hmtf]]
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[[Category: Human mitochondrial ferritin]]
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[[Category: Oxidoreductase]]
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[[Category: Peroxide anion]]
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[[Category: Time-controlled iron loading]]
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Current revision

Crystal structure of human mitochondrial ferritin (hMTF) Fe(II)-loaded for 5 minutes showing a peroxide anion as bridging species of iron ions in the ferroxidase site

PDB ID 7o69

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