This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


7q84

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
m (Protected "7q84" [edit=sysop:move=sysop])
Current revision (13:15, 1 February 2024) (edit) (undo)
 
(2 intermediate revisions not shown.)
Line 1: Line 1:
-
'''Unreleased structure'''
 
-
The entry 7q84 is ON HOLD
+
==Crystal structure of human peroxisomal acyl-Co-A oxidase 1a, apo-form==
 +
<StructureSection load='7q84' size='340' side='right'caption='[[7q84]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
 +
== Structural highlights ==
 +
<table><tr><td colspan='2'>[[7q84]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q84 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q84 FirstGlance]. <br>
 +
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
 +
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
 +
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q84 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q84 OCA], [https://pdbe.org/7q84 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q84 RCSB], [https://www.ebi.ac.uk/pdbsum/7q84 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q84 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/A0A024R8L7_HUMAN A0A024R8L7_HUMAN]
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
Peroxisomal acyl-CoA oxidase 1a (ACOX1a) catalyzes the first and rate-limiting step of fatty acid oxidation, the conversion of acyl-CoAs to 2-trans-enoyl-CoAs. The dysfunction of human ACOX1a (hACOX1a) leads to deterioration of the nervous system manifesting in myeloneuropathy, hypotonia and convulsions. Crystal structures of hACOX1a in apo- and cofactor (FAD)-bound forms were solved at 2.00 and 2.09 A resolution, respectively. hACOX1a exists as a homo-dimer with solvation free energy gain (DeltaG(o)) of -44.7 kcal mol(-1). Two FAD molecules bind at the interface of protein monomers completing the active sites. The substrate binding cleft of hACOX1a is wider compared to human mitochondrial very-long chain specific acyl-CoA dehydrogenase. Mutations (p.G178C, p.M278V and p.N237S) reported to cause dysfunctionality of hACOX1a are analyzed on its 3D-structure to understand structure-function related perturbations and explain the associated phenotypes.
-
Authors: Sonani, R.R., Blat, A., Dubin, G.
+
Crystal structures of apo- and FAD-bound human peroxisomal acyl-CoA oxidase provide mechanistic basis explaining clinical observations.,Sonani RR, Blat A, Dubin G Int J Biol Macromol. 2022 Feb 8;205:203-210. doi: 10.1016/j.ijbiomac.2022.02.008. PMID:35149097<ref>PMID:35149097</ref>
-
Description: Crystal structure of human peroxisomal acyl-Co-A oxidase 1a, apo-form
+
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-
[[Category: Unreleased Structures]]
+
</div>
-
[[Category: Sonani, R.R]]
+
<div class="pdbe-citations 7q84" style="background-color:#fffaf0;"></div>
-
[[Category: Dubin, G]]
+
== References ==
-
[[Category: Blat, A]]
+
<references/>
 +
__TOC__
 +
</StructureSection>
 +
[[Category: Homo sapiens]]
 +
[[Category: Large Structures]]
 +
[[Category: Blat A]]
 +
[[Category: Dubin G]]
 +
[[Category: Sonani RR]]

Current revision

Crystal structure of human peroxisomal acyl-Co-A oxidase 1a, apo-form

PDB ID 7q84

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/7q84"
Personal tools