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7qbg
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==TC:CD320 in complex with nanobody TC-Nb4== | |
| - | + | <StructureSection load='7qbg' size='340' side='right'caption='[[7qbg]], [[Resolution|resolution]] 2.69Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[7qbg]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Vicugna_pacos Vicugna pacos]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QBG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QBG FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.69Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CNC:CO-CYANOCOBALAMIN'>CNC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qbg OCA], [https://pdbe.org/7qbg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qbg RCSB], [https://www.ebi.ac.uk/pdbsum/7qbg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qbg ProSAT]</span></td></tr> |
| - | [[Category: Bloch | + | </table> |
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/TCO2_HUMAN TCO2_HUMAN] Defects in TCN2 are the cause of transcobalamin II deficiency (TCN2 deficiency) [MIM:[https://omim.org/entry/275350 275350]. This results in various forms of anemia. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TCO2_HUMAN TCO2_HUMAN] Primary vitamin B12-binding and transport protein. Delivers cobalamin to cells. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Vicugna pacos]] | ||
| + | [[Category: Bloch JS]] | ||
| + | [[Category: Locher KP]] | ||
Current revision
TC:CD320 in complex with nanobody TC-Nb4
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