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7r27

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<StructureSection load='7r27' size='340' side='right'caption='[[7r27]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
<StructureSection load='7r27' size='340' side='right'caption='[[7r27]], [[Resolution|resolution]] 2.01&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7r27]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R27 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R27 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7r27]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lactiplantibacillus_plantarum_subsp._plantarum_NC8 Lactiplantibacillus plantarum subsp. plantarum NC8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R27 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R27 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.01&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/D-alanine--[D-alanyl-carrier_protein]_ligase D-alanine--[D-alanyl-carrier protein] ligase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.2.1.54 6.2.1.54] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AMP:ADENOSINE+MONOPHOSPHATE'>AMP</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r27 OCA], [https://pdbe.org/7r27 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r27 RCSB], [https://www.ebi.ac.uk/pdbsum/7r27 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r27 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r27 OCA], [https://pdbe.org/7r27 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r27 RCSB], [https://www.ebi.ac.uk/pdbsum/7r27 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r27 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/A0A151G8K4_LACPN A0A151G8K4_LACPN]] Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.[HAMAP-Rule:MF_00593]
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[https://www.uniprot.org/uniprot/A0A151G8K4_LACPN A0A151G8K4_LACPN] Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.[HAMAP-Rule:MF_00593]
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lactiplantibacillus plantarum subsp. plantarum NC8]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Grangeasse, C]]
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[[Category: Grangeasse C]]
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[[Category: Nikolopoulos, N]]
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[[Category: Nikolopoulos N]]
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[[Category: Ravaud, S]]
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[[Category: Ravaud S]]
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[[Category: Simorre, J P]]
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[[Category: Simorre JP]]
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[[Category: Amp intermediate]]
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[[Category: Cytosolic protein]]
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[[Category: D-alanine ligase]]
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[[Category: D-alanylation]]
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[[Category: Teichoic acid]]
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Current revision

Crystal structure of the L. plantarum D-alanine ligase DltA

PDB ID 7r27

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