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7r4o
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 7r4o is ON HOLD Authors: Mackinnon, S., Bezerra, G.A., Krojer, T., Bradley, A.R., Talon, R., Brandeo-Neto, J., Douangamath, A., von Delft, F., Arrow...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of human hydroxyacid oxidase 1 bound with 2-((4H-1,2,4-triazol-3-yl)thio)-1-(4-(3-chlorophenyl)piperazin-1-yl)ethan-1-one== | |
| + | <StructureSection load='7r4o' size='340' side='right'caption='[[7r4o]], [[Resolution|resolution]] 1.50Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[7r4o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R4O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R4O FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=I2W:2-((4H-1,2,4-triazol-3-yl)thio)-1-(4-(3-chlorophenyl)piperazin-1-yl)ethan-1-one'>I2W</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r4o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r4o OCA], [https://pdbe.org/7r4o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r4o RCSB], [https://www.ebi.ac.uk/pdbsum/7r4o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r4o ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HAOX1_HUMAN HAOX1_HUMAN] Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate. | ||
| - | + | ==See Also== | |
| - | + | *[[Glycolate oxidase 3D structures|Glycolate oxidase 3D structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Arrowsmith CH]] |
| - | [[Category: | + | [[Category: Bezerra GA]] |
| - | [[Category: | + | [[Category: Bountra C]] |
| - | [[Category: | + | [[Category: Bradley AR]] |
| - | [[Category: | + | [[Category: Brandeo-Neto J]] |
| - | [[Category: | + | [[Category: Brennan PE]] |
| - | [[Category: Edwards | + | [[Category: Douangamath A]] |
| - | [[Category: | + | [[Category: Edwards A]] |
| - | [[Category: | + | [[Category: Krojer T]] |
| - | [[Category: | + | [[Category: Mackinnon S]] |
| - | [[Category: | + | [[Category: Oppermann U]] |
| - | [[Category: | + | [[Category: Talon R]] |
| + | [[Category: Yue WW]] | ||
| + | [[Category: Von Delft F]] | ||
Current revision
Structure of human hydroxyacid oxidase 1 bound with 2-((4H-1,2,4-triazol-3-yl)thio)-1-(4-(3-chlorophenyl)piperazin-1-yl)ethan-1-one
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bezerra GA | Bountra C | Bradley AR | Brandeo-Neto J | Brennan PE | Douangamath A | Edwards A | Krojer T | Mackinnon S | Oppermann U | Talon R | Yue WW | Von Delft F
