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1r9u

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{{Seed}}
 
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[[Image:1r9u.png|left|200px]]
 
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==Refined structure of peptaibol zervamicin IIB in methanol solution from trans-hydrogen bond J couplings==
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The line below this paragraph, containing "STRUCTURE_1r9u", creates the "Structure Box" on the page.
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<StructureSection load='1r9u' size='340' side='right'caption='[[1r9u]]' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1r9u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Emericellopsis_salmosynnemata Emericellopsis salmosynnemata]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R9U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1R9U FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB</scene>, <scene name='pdbligand=DIV:D-ISOVALINE'>DIV</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=PHL:L-PHENYLALANINOL'>PHL</scene>, <scene name='pdbligand=PRD_000159:Zervamicin+IIB'>PRD_000159</scene></td></tr>
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{{STRUCTURE_1r9u| PDB=1r9u | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1r9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r9u OCA], [https://pdbe.org/1r9u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1r9u RCSB], [https://www.ebi.ac.uk/pdbsum/1r9u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1r9u ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Zervamicin IIB is a member of the alpha-aminoisobutyric acid containing peptaibol antibiotics. A new procedure for the biosynthetic preparation of the uniformly 13C- and 15N-enriched peptaibol is described This compound was isolated from the biomass of the fungus-producer Emericellopsis salmosynnemata strain 336 IMI 58330 obtained upon cultivation in the totally 13C, 15N-labelled complete medium. To prepare such a medium the autolysed biomass and the exopolysaccharides of the obligate methylotrophic bacterium Methylobacillus flagellatus KT were used. This microorganism was grown in totally 13C, 15N-labelled minimal medium containing 13C-methanol and 15N-ammonium chloride as the only carbon and nitrogen sources. Preliminary NMR spectroscopic analysis indicated a high extent of isotope incorporation (&gt; 90%) and led to the complete 13C- and 15N-NMR assignment including the stereospecific assignment of Aib residues methyl groups. The observed pattern of the structurally important secondary chemical shifts of 1H(alpha), 13C=O and 13C(alpha) agrees well with the previously determined structure of zervamicin IIB in methanol solution.
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===Refined structure of peptaibol zervamicin IIB in methanol solution from trans-hydrogen bond J couplings===
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Biosynthetic uniform 13C,15N-labelling of zervamicin IIB. Complete 13C and 15N NMR assignment.,Ovchinnikova TV, Shenkarev ZO, Yakimenko ZA, Svishcheva NV, Tagaev AA, Skladnev DA, Arseniev AS J Pept Sci. 2003 Nov-Dec;9(11-12):817-26. PMID:14658801<ref>PMID:14658801</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_15189865}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 1r9u" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 15189865 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_15189865}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Emericellopsis salmosynnemata]]
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R9U OCA].
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[[Category: Large Structures]]
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[[Category: Arseniev AS]]
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==Reference==
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[[Category: Balashova TA]]
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Peptaibol zervamicin IIb structure and dynamics refinement from transhydrogen bond J couplings., Shenkarev ZO, Balashova TA, Yakimenko ZA, Ovchinnikova TV, Arseniev AS, Biophys J. 2004 Jun;86(6):3687-99. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15189865 15189865]
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[[Category: Ovchinnikova TV]]
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[[Category: Arseniev, A S.]]
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[[Category: Shenkarev ZO]]
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[[Category: Balashova, T A.]]
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[[Category: Yakimenko ZA]]
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[[Category: Ovchinnikova, T V.]]
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[[Category: Shenkarev, Z O.]]
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[[Category: Yakimenko, Z A.]]
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[[Category: Bent helix]]
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[[Category: Bifurcated hydrogen bond]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 16:49:16 2008''
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Current revision

Refined structure of peptaibol zervamicin IIB in methanol solution from trans-hydrogen bond J couplings

PDB ID 1r9u

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