2y6c

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[[Image:2y6c.jpg|left|200px]]
 
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==The Discovery of MMP7 inhibitors Exploiting a Novel Selectivity Trigger==
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The line below this paragraph, containing "STRUCTURE_2y6c", creates the "Structure Box" on the page.
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<StructureSection load='2y6c' size='340' side='right'caption='[[2y6c]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2y6c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y6C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y6C FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TQI:N-{[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]SULFONYL}-L-TRYPTOPHAN'>TQI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_2y6c| PDB=2y6c | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y6c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y6c OCA], [https://pdbe.org/2y6c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y6c RCSB], [https://www.ebi.ac.uk/pdbsum/2y6c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y6c ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MMP7_HUMAN MMP7_HUMAN] Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.<ref>PMID:2550050</ref>
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===THE DISCOVERY OF MMP7 INHIBITORS EXPLOITING A NOVEL SELECTIVITY TRIGGER===
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==See Also==
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*[[Matrix metalloproteinase 3D structures|Matrix metalloproteinase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[2y6c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y6C OCA].
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__TOC__
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</StructureSection>
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==Reference==
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<ref group="xtra">PMID:021520417</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Matrilysin]]
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[[Category: Large Structures]]
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[[Category: Edman, K.]]
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[[Category: Edman K]]
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[[Category: Furber, M.]]
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[[Category: Furber M]]
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[[Category: Hemsley, P.]]
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[[Category: Hemsley P]]
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[[Category: Johansson, C.]]
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[[Category: Johansson C]]
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[[Category: Pairaudeau, G.]]
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[[Category: Pairaudeau G]]
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[[Category: Petersen, J.]]
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[[Category: Petersen J]]
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[[Category: Stocks, M.]]
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[[Category: Stocks M]]
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[[Category: Tervo, A.]]
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[[Category: Tervo A]]
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[[Category: Ward, A.]]
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[[Category: Ward A]]
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[[Category: Wells, E.]]
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[[Category: Wells E]]
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[[Category: Wissler, L.]]
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[[Category: Wissler L]]

Current revision

The Discovery of MMP7 inhibitors Exploiting a Novel Selectivity Trigger

PDB ID 2y6c

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