This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2y6c
From Proteopedia
(Difference between revisions)
| (One intermediate revision not shown.) | |||
| Line 3: | Line 3: | ||
<StructureSection load='2y6c' size='340' side='right'caption='[[2y6c]], [[Resolution|resolution]] 1.70Å' scene=''> | <StructureSection load='2y6c' size='340' side='right'caption='[[2y6c]], [[Resolution|resolution]] 1.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2y6c]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2y6c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y6C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y6C FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TQI:N-{[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]SULFONYL}-L-TRYPTOPHAN'>TQI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TQI:N-{[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]SULFONYL}-L-TRYPTOPHAN'>TQI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y6c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y6c OCA], [https://pdbe.org/2y6c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y6c RCSB], [https://www.ebi.ac.uk/pdbsum/2y6c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y6c ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/MMP7_HUMAN MMP7_HUMAN] Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.<ref>PMID:2550050</ref> |
==See Also== | ==See Also== | ||
| Line 18: | Line 17: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | + | [[Category: Edman K]] | |
| - | [[Category: Edman | + | [[Category: Furber M]] |
| - | [[Category: Furber | + | [[Category: Hemsley P]] |
| - | [[Category: Hemsley | + | [[Category: Johansson C]] |
| - | [[Category: Johansson | + | [[Category: Pairaudeau G]] |
| - | [[Category: Pairaudeau | + | [[Category: Petersen J]] |
| - | [[Category: Petersen | + | [[Category: Stocks M]] |
| - | [[Category: Stocks | + | [[Category: Tervo A]] |
| - | [[Category: Tervo | + | [[Category: Ward A]] |
| - | [[Category: Ward | + | [[Category: Wells E]] |
| - | [[Category: Wells | + | [[Category: Wissler L]] |
| - | [[Category: Wissler | + | |
| - | + | ||
Current revision
The Discovery of MMP7 inhibitors Exploiting a Novel Selectivity Trigger
| |||||||||||
Categories: Homo sapiens | Large Structures | Edman K | Furber M | Hemsley P | Johansson C | Pairaudeau G | Petersen J | Stocks M | Tervo A | Ward A | Wells E | Wissler L
