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2y6c
From Proteopedia
(Difference between revisions)
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<StructureSection load='2y6c' size='340' side='right'caption='[[2y6c]], [[Resolution|resolution]] 1.70Å' scene=''> | <StructureSection load='2y6c' size='340' side='right'caption='[[2y6c]], [[Resolution|resolution]] 1.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2y6c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2y6c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Y6C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Y6C FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TQI:N-{[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]SULFONYL}-L-TRYPTOPHAN'>TQI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TQI:N-{[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]SULFONYL}-L-TRYPTOPHAN'>TQI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | + | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y6c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y6c OCA], [https://pdbe.org/2y6c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y6c RCSB], [https://www.ebi.ac.uk/pdbsum/2y6c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y6c ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2y6c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2y6c OCA], [https://pdbe.org/2y6c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2y6c RCSB], [https://www.ebi.ac.uk/pdbsum/2y6c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2y6c ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/MMP7_HUMAN MMP7_HUMAN] Degrades casein, gelatins of types I, III, IV, and V, and fibronectin. Activates procollagenase.<ref>PMID:2550050</ref> | |
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | + | [[Category: Edman K]] | |
| - | [[Category: Edman | + | [[Category: Furber M]] |
| - | [[Category: Furber | + | [[Category: Hemsley P]] |
| - | [[Category: Hemsley | + | [[Category: Johansson C]] |
| - | [[Category: Johansson | + | [[Category: Pairaudeau G]] |
| - | [[Category: Pairaudeau | + | [[Category: Petersen J]] |
| - | [[Category: Petersen | + | [[Category: Stocks M]] |
| - | [[Category: Stocks | + | [[Category: Tervo A]] |
| - | [[Category: Tervo | + | [[Category: Ward A]] |
| - | [[Category: Ward | + | [[Category: Wells E]] |
| - | [[Category: Wells | + | [[Category: Wissler L]] |
| - | [[Category: Wissler | + | |
| - | + | ||
Current revision
The Discovery of MMP7 inhibitors Exploiting a Novel Selectivity Trigger
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Categories: Homo sapiens | Large Structures | Edman K | Furber M | Hemsley P | Johansson C | Pairaudeau G | Petersen J | Stocks M | Tervo A | Ward A | Wells E | Wissler L
