2yeq

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (14:03, 1 February 2024) (edit) (undo)
 
(7 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:2yeq.jpg|left|200px]]
 
-
<!--
+
==Structure of PhoD==
-
The line below this paragraph, containing "STRUCTURE_2yeq", creates the "Structure Box" on the page.
+
<StructureSection load='2yeq' size='340' side='right'caption='[[2yeq]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[2yeq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YEQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YEQ FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.93&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=PE5:3,6,9,12,15,18,21,24-OCTAOXAHEXACOSAN-1-OL'>PE5</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
-
{{STRUCTURE_2yeq| PDB=2yeq | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yeq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yeq OCA], [https://pdbe.org/2yeq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yeq RCSB], [https://www.ebi.ac.uk/pdbsum/2yeq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yeq ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/PPBD_BACSU PPBD_BACSU]
 +
<div style="background-color:#fffaf0;">
 +
== Publication Abstract from PubMed ==
 +
The PhoD family of extracytoplasmic phosphodiesterases are amongst the most commonly occurring bacterial phosphatases. The exemplars for this family are the PhoD protein of Bacillus subtilis and the phospholipase D of Streptomyces chromofuscus. We present the crystal structure of B. subtilis PhoD. PhoD is most closely related to purple acid phosphatases (PAPs) with both types of enzyme containing a tyrosinate-ligated Fe3+ ion. However, the PhoD active site diverges from that found in PAPs and uses two Ca2+ ions instead of the single extra Fe2+, Mn2+, or Zn2+ ion present in PAPs. The PhoD crystals contain a phosphate molecule that co-ordinates all three active site metal ions and which is proposed to represent a product complex. A C-terminal helix lies over the active site and controls access to the catalytic centre. The structure of PhoD defines a new phosphatase active site architecture based on Fe3+ and Ca2+ ions.
-
===Structure of PhoD===
+
Crystal Structure of the Bacillus subtilis Phosphodiesterase PhoD Reveals an Iron and Calcium-Containing Active Site.,Rodriguez F, Lillington J, Johnson S, Timmel CR, Lea SM, Berks BC J Biol Chem. 2014 Sep 12. pii: jbc.M114.604892. PMID:25217636<ref>PMID:25217636</ref>
 +
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 +
</div>
 +
<div class="pdbe-citations 2yeq" style="background-color:#fffaf0;"></div>
-
==About this Structure==
+
==See Also==
-
[[2yeq]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YEQ OCA].
+
*[[Alkaline phosphatase 3D structures|Alkaline phosphatase 3D structures]]
-
[[Category: Alkaline phosphatase]]
+
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
-
[[Category: Berks, B.]]
+
[[Category: Large Structures]]
-
[[Category: Johnson, S J.]]
+
[[Category: Berks B]]
-
[[Category: Lea, S M.]]
+
[[Category: Johnson SJ]]
-
[[Category: Lillington, J E.D.]]
+
[[Category: Lea SM]]
-
[[Category: Rodriguez, F.]]
+
[[Category: Lillington JED]]
-
[[Category: Roversi, P.]]
+
[[Category: Rodriguez F]]
-
[[Category: Hydrolase]]
+
[[Category: Roversi P]]
-
[[Category: Phosphodiesterase]]
+

Current revision

Structure of PhoD

PDB ID 2yeq

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2yeq"
Personal tools