2yll

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[[Image:2yll.png|left|200px]]
 
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==Inhibition of the pneumococcal virulence factor StrH and molecular insights into N-glycan recognition and hydrolysis==
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The line below this paragraph, containing "STRUCTURE_2yll", creates the "Structure Box" on the page.
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<StructureSection load='2yll' size='340' side='right'caption='[[2yll]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[2yll]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_TIGR4 Streptococcus pneumoniae TIGR4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YLL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2YLL FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=PE4:2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL'>PE4</scene></td></tr>
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{{STRUCTURE_2yll| PDB=2yll | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2yll FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yll OCA], [https://pdbe.org/2yll PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2yll RCSB], [https://www.ebi.ac.uk/pdbsum/2yll PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2yll ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/STRH_STRPN STRH_STRPN]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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The complete degradation of N-linked glycans by the pathogenic bacterium Streptococcus pneumoniae is facilitated by the large multimodular cell wall-attached exo-beta-D-N-acetylglucosaminidase StrH. Structural dissection of this virulence factor using X-ray crystallography showed it to have two structurally related glycoside hydrolase family 20 catalytic domains, which displayed the expected specificity for complex N-glycans terminating in N-acetylglucosamine but exhibited unexpected differences in their preferences for the substructures present in these glycans. The structures of the two catalytic domains in complex with unhydrolyzed substrates, including an N-glycan possessing a bisecting N-acetylglucosamine residue, revealed the specific architectural features in the active sites that confer their differential specificities. Inhibitors of StrH are demonstrated to be effective tools in modulating the interaction of StrH with components of the host, such as the innate immune system. Overall, new structural and functional insight into a carbohydrate-mediated component of the pneumococcus-host interaction is provided.
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===INHIBITION OF THE PNEUMOCOCCAL VIRULENCE FACTOR STRH AND MOLECULAR INSIGHTS INTO N-GLYCAN RECOGNITION AND HYDROLYSIS===
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Inhibition of the Pneumococcal Virulence Factor StrH and Molecular Insights into N-Glycan Recognition and Hydrolysis.,Pluvinage B, Higgins MA, Abbott DW, Robb C, Dalia AB, Deng L, Weiser JN, Parsons TB, Fairbanks AJ, Vocadlo DJ, Boraston AB Structure. 2011 Nov 9;19(11):1603-14. PMID:22078560<ref>PMID:22078560</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2yll" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Beta-Hexosaminidase|Beta-Hexosaminidase]]
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(as it appears on PubMed at http://www.pubmed.gov), where 22078560 is the PubMed ID number.
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*[[Beta-Hexosaminidase 3D structures|Beta-Hexosaminidase 3D structures]]
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*[[Beta-N-acetylhexosaminidase 3D structures|Beta-N-acetylhexosaminidase 3D structures]]
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{{ABSTRACT_PUBMED_22078560}}
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== References ==
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<references/>
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==About this Structure==
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__TOC__
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[[2yll]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YLL OCA].
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</StructureSection>
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[[Category: Large Structures]]
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==Reference==
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[[Category: Streptococcus pneumoniae TIGR4]]
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<ref group="xtra">PMID:022078560</ref><references group="xtra"/>
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[[Category: Abbott DW]]
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[[Category: Beta-N-acetylhexosaminidase]]
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[[Category: Boraston AB]]
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[[Category: Streptococcus pneumoniae]]
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[[Category: Dalia AB]]
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[[Category: Abbott, D W.]]
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[[Category: Deng L]]
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[[Category: Boraston, A B.]]
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[[Category: Fairbanks AJ]]
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[[Category: Dalia, A B.]]
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[[Category: Higgins MA]]
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[[Category: Deng, L.]]
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[[Category: Parsons TB]]
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[[Category: Fairbanks, A J.]]
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[[Category: Pluvinage B]]
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[[Category: Higgins, M A.]]
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[[Category: Robb C]]
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[[Category: Parsons, T B.]]
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[[Category: Vocadlo DJ]]
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[[Category: Pluvinage, B.]]
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[[Category: Weiser JN]]
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[[Category: Robb, C.]]
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[[Category: Vocadlo, D J.]]
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[[Category: Weiser, J N.]]
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[[Category: Hydrolase]]
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Current revision

Inhibition of the pneumococcal virulence factor StrH and molecular insights into N-glycan recognition and hydrolysis

PDB ID 2yll

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