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5qc5
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==Crystal structure of human Cathepsin-S with bound ligand== | ==Crystal structure of human Cathepsin-S with bound ligand== | ||
| - | <StructureSection load='5qc5' size='340' side='right' caption='[[5qc5]], [[Resolution|resolution]] 2.40Å' scene=''> | + | <StructureSection load='5qc5' size='340' side='right'caption='[[5qc5]], [[Resolution|resolution]] 2.40Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5qc5]] is a 2 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[5qc5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QC5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QC5 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BAJ:1-[5-{1-[3-(4-tert-butylpiperidin-1-yl)propyl]-5-(methylsulfonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl}-2-(trifluoromethyl)phenyl]-N-[(4-fluorophenyl)methyl]methanamine'>BAJ</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BAJ:1-[5-{1-[3-(4-tert-butylpiperidin-1-yl)propyl]-5-(methylsulfonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl}-2-(trifluoromethyl)phenyl]-N-[(4-fluorophenyl)methyl]methanamine'>BAJ</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qc5 OCA], [https://pdbe.org/5qc5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qc5 RCSB], [https://www.ebi.ac.uk/pdbsum/5qc5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qc5 ProSAT]</span></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/CATS_HUMAN CATS_HUMAN] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N. |
==See Also== | ==See Also== | ||
| - | *[[Cathepsin|Cathepsin]] | + | *[[Cathepsin 3D structures|Cathepsin 3D structures]] |
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Ameriks | + | [[Category: Ameriks MK]] |
| - | [[Category: Bembenek | + | [[Category: Bembenek SD]] |
| - | [[Category: Burley | + | [[Category: Burley SK]] |
| - | [[Category: Mirzadegan | + | [[Category: Mirzadegan T]] |
| - | [[Category: Shao | + | [[Category: Shao C]] |
| - | [[Category: Yang | + | [[Category: Yang H]] |
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Current revision
Crystal structure of human Cathepsin-S with bound ligand
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Categories: Homo sapiens | Large Structures | Ameriks MK | Bembenek SD | Burley SK | Mirzadegan T | Shao C | Yang H
