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5qc8

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==Crystal structure of human Cathepsin-S with bound ligand==
==Crystal structure of human Cathepsin-S with bound ligand==
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<StructureSection load='5qc8' size='340' side='right' caption='[[5qc8]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
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<StructureSection load='5qc8' size='340' side='right'caption='[[5qc8]], [[Resolution|resolution]] 1.74&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[5qc8]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QC8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5QC8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[5qc8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5QC8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5QC8 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BFV:N-benzyl-1-{3-[(2-chloro-5-{5-(methylsulfonyl)-1-[3-(morpholin-4-yl)propyl]-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl}phenyl)ethynyl]phenyl}methanamine'>BFV</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.74&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Cathepsin_S Cathepsin S], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.27 3.4.22.27] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BFV:N-benzyl-1-{3-[(2-chloro-5-{5-(methylsulfonyl)-1-[3-(morpholin-4-yl)propyl]-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl}phenyl)ethynyl]phenyl}methanamine'>BFV</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5qc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qc8 OCA], [http://pdbe.org/5qc8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5qc8 RCSB], [http://www.ebi.ac.uk/pdbsum/5qc8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5qc8 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5qc8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5qc8 OCA], [https://pdbe.org/5qc8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5qc8 RCSB], [https://www.ebi.ac.uk/pdbsum/5qc8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5qc8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/CATS_HUMAN CATS_HUMAN]] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.
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[https://www.uniprot.org/uniprot/CATS_HUMAN CATS_HUMAN] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.
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==See Also==
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*[[Cathepsin 3D structures|Cathepsin 3D structures]]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Cathepsin S]]
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[[Category: Homo sapiens]]
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[[Category: Ameriks, M K]]
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[[Category: Large Structures]]
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[[Category: Bembenek, S D]]
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[[Category: Ameriks MK]]
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[[Category: Burley, S K]]
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[[Category: Bembenek SD]]
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[[Category: Mirzadegan, T]]
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[[Category: Burley SK]]
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[[Category: Shao, C]]
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[[Category: Mirzadegan T]]
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[[Category: Yang, H]]
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[[Category: Shao C]]
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[[Category: Cathepsin s]]
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[[Category: Yang H]]
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[[Category: D3r]]
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[[Category: Hydrolase]]
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[[Category: Ligand docking]]
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Current revision

Crystal structure of human Cathepsin-S with bound ligand

PDB ID 5qc8

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