111d

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[[Image:111d.jpg|left|200px]]
 
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==CRYSTAL STRUCTURE AND STABILITY OF A DNA DUPLEX CONTAINING A(ANTI).G(SYN) BASE-PAIRS==
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The line below this paragraph, containing "STRUCTURE_111d", creates the "Structure Box" on the page.
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<StructureSection load='111d' size='340' side='right'caption='[[111d]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[111d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=111D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=111D FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=111d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=111d OCA], [https://pdbe.org/111d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=111d RCSB], [https://www.ebi.ac.uk/pdbsum/111d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=111d ProSAT]</span></td></tr>
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{{STRUCTURE_111d| PDB=111d | SCENE= }}
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</table>
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__TOC__
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'''CRYSTAL STRUCTURE AND STABILITY OF A DNA DUPLEX CONTAINING A(ANTI).G(SYN) BASE-PAIRS'''
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Booth ED]]
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==Overview==
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[[Category: Brown T]]
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The synthetic dodecanucleotide d(CGCAAATTGGCG) has been analysed by single-crystal X-ray diffraction techniques and the structure refined to R = 0.16 and 2.25 A resolution, with the location of 94 solvent molecules. The sequence crystallizes as a full turn of a B-DNA helix with ten Watson-Crick base-pairs and two adenine-guanine mispairs. The analysis clearly shows that the mismatches are of the form A(anti).G(syn). Thermal denaturation studies indicate that the stability of the duplex is strongly pH dependent, with a maximum at pH 5.0, suggesting that the base-pair is stabilized by protonation. Three different arrangements have been observed for base-pairs between guanine and adenine and it is likely that A.G mismatch conformation is strongly influenced by dipole-dipole interactions with adjacent base-pairs.
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[[Category: Chambers J]]
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[[Category: Leonard GA]]
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==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=111D OCA].
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==Reference==
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Crystal structure and stability of a DNA duplex containing A(anti).G(syn) base-pairs., Brown T, Leonard GA, Booth ED, Chambers J, J Mol Biol. 1989 May 20;207(2):455-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/2754734 2754734]
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[[Category: Booth, E D.]]
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[[Category: Brown, T.]]
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[[Category: Chambers, J.]]
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[[Category: Leonard, G A.]]
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[[Category: B-dna]]
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[[Category: Double helix]]
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[[Category: Mismatched]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 09:25:59 2008''
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Current revision

CRYSTAL STRUCTURE AND STABILITY OF A DNA DUPLEX CONTAINING A(ANTI).G(SYN) BASE-PAIRS

PDB ID 111d

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