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180d

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(New page: 200px<br /><applet load="180d" size="450" color="white" frame="true" align="right" spinBox="true" caption="180d, resolution 2.500&Aring;" /> '''SEQUENCE-DEPENDENT ...)
Current revision (06:25, 7 February 2024) (edit) (undo)
 
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[[Image:180d.gif|left|200px]]<br /><applet load="180d" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="180d, resolution 2.500&Aring;" />
 
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'''SEQUENCE-DEPENDENT MICROHETEROGENEITY OF Z-DNA: THE CRYSTAL AND MOLECULAR STRUCTURES OF D(CACGCG).D(CGCGTG) AND D(CGCACG).D(CGTGCG)'''<br />
 
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==Overview==
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==SEQUENCE-DEPENDENT MICROHETEROGENEITY OF Z-DNA: THE CRYSTAL AND MOLECULAR STRUCTURES OF D(CACGCG).D(CGCGTG) AND D(CGCACG).D(CGTGCG)==
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We have solved and refined the crystal structures of the first two, non-self-complementary hexadeoxyribonucleotide duplexes with Watson-Crick, base pairs, namely d(CACGCG).d(CGCGTG) and d(CGCACG).d(CGTGCG). Both the, hexamers crystallize in the left-handed Z-DNA conformation. The packing of, the molecules is similar in the two crystals: the hexamers are stacked on, top of each other to form columns of infinite length, which are arranged, in a close-packed hexagonal pattern. In spite of the similar packing, crystals of the first duplex belong to the space group P2(1)2(1)2(1), isomorphous to previous Z-DNA hexamers, while crystals of the other duplex, belong to the space group P2(1), which has not been observed before in, this context. The molecular structures of the two duplexes are also, different. The first is very similar in conformation to the other Z-DNA, hexamers and to the idealized ZI model. The other duplex shows large, differences in the stacking and the relative disposition of its bases, leading to its possible classification as a novel Z-DNA variant. We, conclude that the differences in the structure under similar environmental, conditions point to a sequence-dependent plasticity in the DNA molecule, which is visible even under close-packed conditions.
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<StructureSection load='180d' size='340' side='right'caption='[[180d]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[180d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=180D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=180D FirstGlance]. <br>
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180D is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=180D OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=180d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=180d OCA], [https://pdbe.org/180d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=180d RCSB], [https://www.ebi.ac.uk/pdbsum/180d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=180d ProSAT]</span></td></tr>
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==Reference==
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</table>
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Sequence-dependent microheterogeneity of Z-DNA: the crystal and molecular structures of d(CACGCG).d(CGCGTG) and d(CGCACG).d(CGTGCG)., Sadasivan C, Gautham N, J Mol Biol. 1995 May 19;248(5):918-30. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7760333 7760333]
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__TOC__
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[[Category: Protein complex]]
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</StructureSection>
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[[Category: Gautham, N.]]
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[[Category: Large Structures]]
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[[Category: Sadasivan, C.]]
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[[Category: Gautham N]]
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[[Category: double helix]]
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[[Category: Sadasivan C]]
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[[Category: z-dna]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sat Nov 24 22:07:19 2007''
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Current revision

SEQUENCE-DEPENDENT MICROHETEROGENEITY OF Z-DNA: THE CRYSTAL AND MOLECULAR STRUCTURES OF D(CACGCG).D(CGCGTG) AND D(CGCACG).D(CGTGCG)

PDB ID 180d

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