1a12

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{{Seed}}
 
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[[Image:1a12.png|left|200px]]
 
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==REGULATOR OF CHROMOSOME CONDENSATION (RCC1) OF HUMAN==
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The line below this paragraph, containing "STRUCTURE_1a12", creates the "Structure Box" on the page.
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<StructureSection load='1a12' size='340' side='right'caption='[[1a12]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1a12]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A12 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A12 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a12 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a12 OCA], [https://pdbe.org/1a12 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a12 RCSB], [https://www.ebi.ac.uk/pdbsum/1a12 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a12 ProSAT]</span></td></tr>
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{{STRUCTURE_1a12| PDB=1a12 | SCENE= }}
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</table>
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== Function ==
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===REGULATOR OF CHROMOSOME CONDENSATION (RCC1) OF HUMAN===
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[https://www.uniprot.org/uniprot/RCC1_HUMAN RCC1_HUMAN] Guanine-nucleotide releasing factor that promotes the exchange of Ran-bound GDP by GTP. Involved in the regulation of onset of chromosome condensation in the S phase. Binds both to the nucleosomes and double-stranded DNA. RCC1-Ran complex (together with other proteins) acts as a component of a signal transmission pathway that detects unreplicated DNA. Plays a key role in nucleo-cytoplasmic transport, mitosis and nuclear-envelope assembly.<ref>PMID:1944575</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 9510255 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a1/1a12_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_9510255}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a12 ConSurf].
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1A12 is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A12 OCA].
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<div style="clear:both"></div>
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:9510255</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Becker, J.]]
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[[Category: Large Structures]]
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[[Category: Nassar, N.]]
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[[Category: Becker J]]
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[[Category: Renault, L.]]
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[[Category: Nassar N]]
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[[Category: Roth, M.]]
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[[Category: Renault L]]
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[[Category: Vetter, I.]]
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[[Category: Roth M]]
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[[Category: Wittinghofer, A.]]
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[[Category: Vetter I]]
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[[Category: Gef]]
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[[Category: Wittinghofer A]]
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[[Category: Guanine nucleotide exchange factor]]
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[[Category: Ran]]
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[[Category: Ras-like nuclear gtp binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 19:11:27 2009''
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Current revision

REGULATOR OF CHROMOSOME CONDENSATION (RCC1) OF HUMAN

PDB ID 1a12

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