1a1x
From Proteopedia
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| - | [[Image:1a1x.png|left|200px]] | ||
| - | + | ==CRYSTAL STRUCTURE OF MTCP-1 INVOLVED IN T CELL MALIGNANCIES== | |
| - | + | <StructureSection load='1a1x' size='340' side='right'caption='[[1a1x]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[1a1x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A1X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A1X FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a1x OCA], [https://pdbe.org/1a1x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a1x RCSB], [https://www.ebi.ac.uk/pdbsum/1a1x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a1x ProSAT]</span></td></tr> | |
| - | == | + | </table> |
| - | [[1a1x]] is a 1 chain structure with sequence from [ | + | == Disease == |
| - | + | [https://www.uniprot.org/uniprot/MTCP1_HUMAN MTCP1_HUMAN] Note=Detected in T-cell leukemia bearing a t(X;14) translocation. Plays a key role in T-cell prolymphocytic leukemia. | |
| - | == | + | == Function == |
| - | < | + | [https://www.uniprot.org/uniprot/MTCP1_HUMAN MTCP1_HUMAN] Enhances the phosphorylation and activation of AKT1 and AKT2.<ref>PMID:10983986</ref> |
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a1/1a1x_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a1x ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Croce | + | [[Category: Large Structures]] |
| - | [[Category: Dubois | + | [[Category: Croce CM]] |
| - | [[Category: Fu | + | [[Category: Dubois GC]] |
| - | [[Category: Harrison | + | [[Category: Fu ZQ]] |
| - | [[Category: Kulikovskaya | + | [[Category: Harrison RW]] |
| - | [[Category: Rothstein | + | [[Category: Kulikovskaya I]] |
| - | [[Category: Song | + | [[Category: Rothstein J]] |
| - | [[Category: Virgilio | + | [[Category: Song SP]] |
| - | [[Category: Weber | + | [[Category: Virgilio L]] |
| - | + | [[Category: Weber IT]] | |
| - | + | ||
| - | + | ||
Current revision
CRYSTAL STRUCTURE OF MTCP-1 INVOLVED IN T CELL MALIGNANCIES
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Categories: Homo sapiens | Large Structures | Croce CM | Dubois GC | Fu ZQ | Harrison RW | Kulikovskaya I | Rothstein J | Song SP | Virgilio L | Weber IT
