1a1x

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[[Image:1a1x.gif|left|200px]]
 
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{{Structure
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==CRYSTAL STRUCTURE OF MTCP-1 INVOLVED IN T CELL MALIGNANCIES==
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|PDB= 1a1x |SIZE=350|CAPTION= <scene name='initialview01'>1a1x</scene>, resolution 2.0&Aring;
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<StructureSection load='1a1x' size='340' side='right'caption='[[1a1x]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[1a1x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A1X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A1X FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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|GENE=
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a1x OCA], [https://pdbe.org/1a1x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a1x RCSB], [https://www.ebi.ac.uk/pdbsum/1a1x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a1x ProSAT]</span></td></tr>
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}}
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</table>
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== Disease ==
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'''CRYSTAL STRUCTURE OF MTCP-1 INVOLVED IN T CELL MALIGNANCIES'''
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[https://www.uniprot.org/uniprot/MTCP1_HUMAN MTCP1_HUMAN] Note=Detected in T-cell leukemia bearing a t(X;14) translocation. Plays a key role in T-cell prolymphocytic leukemia.
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== Function ==
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[https://www.uniprot.org/uniprot/MTCP1_HUMAN MTCP1_HUMAN] Enhances the phosphorylation and activation of AKT1 and AKT2.<ref>PMID:10983986</ref>
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==Overview==
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== Evolutionary Conservation ==
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Two related oncogenes, TCL-1 and MTCP-1, are overexpressed in T cell prolymphocytic leukemias as a result of chromosomal rearrangements that involve the translocation of one T cell receptor gene to either chromosome 14q32 or Xq28. The crystal structure of human recombinant MTCP-1 protein has been determined at 2.0 A resolution by using multiwavelength anomalous dispersion data from selenomethionine-enriched protein and refined to an R factor of 0.21. MTCP-1 folds into a compact eight-stranded beta barrel structure with a short helix between the fourth and fifth strands. The topology is unique. The structure of TCL-1 has been predicted by molecular modeling based on 40% amino acid sequence identity with MTCP-1. The identical residues are clustered inside the barrel and on the surface at one side of the barrel. The overall structure of MTCP-1 superficially resembles the structures of proteins in the lipocalin family and calycin superfamily. These proteins have diverse functions, including transport of retinol, fatty acids, chromophores, pheromones, synthesis of prostaglandin, immune modulation, and cell regulation. However, MTCP-1 differs in the topology of the beta strands. The structural similarity suggests that MTCP-1 and TCL-1 form a unique family of beta barrel proteins that is predicted to bind small hydrophobic ligands and function in cell regulation.
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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==About this Structure==
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<jmolCheckbox>
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1A1X is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A1X OCA].
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a1/1a1x_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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==Reference==
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<text>to colour the structure by Evolutionary Conservation</text>
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Crystal structure of MTCP-1: implications for role of TCL-1 and MTCP-1 in T cell malignancies., Fu ZQ, Du Bois GC, Song SP, Kulikovskaya I, Virgilio L, Rothstein JL, Croce CM, Weber IT, Harrison RW, Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3413-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9520380 9520380]
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a1x ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Croce, C M.]]
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[[Category: Croce CM]]
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[[Category: Dubois, G C.]]
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[[Category: Dubois GC]]
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[[Category: Fu, Z Q.]]
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[[Category: Fu ZQ]]
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[[Category: Harrison, R W.]]
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[[Category: Harrison RW]]
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[[Category: Kulikovskaya, I.]]
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[[Category: Kulikovskaya I]]
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[[Category: Rothstein, J.]]
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[[Category: Rothstein J]]
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[[Category: Song, S P.]]
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[[Category: Song SP]]
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[[Category: Virgilio, L.]]
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[[Category: Virgilio L]]
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[[Category: Weber, I T.]]
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[[Category: Weber IT]]
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[[Category: crystal structure]]
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[[Category: mtcp-1]]
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[[Category: oncogene involved in t cell malignancy]]
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[[Category: proto-oncogene]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 09:51:42 2008''
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Current revision

CRYSTAL STRUCTURE OF MTCP-1 INVOLVED IN T CELL MALIGNANCIES

PDB ID 1a1x

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