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1a1x

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{{Seed}}
 
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[[Image:1a1x.png|left|200px]]
 
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==CRYSTAL STRUCTURE OF MTCP-1 INVOLVED IN T CELL MALIGNANCIES==
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The line below this paragraph, containing "STRUCTURE_1a1x", creates the "Structure Box" on the page.
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<StructureSection load='1a1x' size='340' side='right'caption='[[1a1x]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[1a1x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A1X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1A1X FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1a1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1a1x OCA], [https://pdbe.org/1a1x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1a1x RCSB], [https://www.ebi.ac.uk/pdbsum/1a1x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1a1x ProSAT]</span></td></tr>
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{{STRUCTURE_1a1x| PDB=1a1x | SCENE= }}
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</table>
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== Disease ==
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===CRYSTAL STRUCTURE OF MTCP-1 INVOLVED IN T CELL MALIGNANCIES===
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[https://www.uniprot.org/uniprot/MTCP1_HUMAN MTCP1_HUMAN] Note=Detected in T-cell leukemia bearing a t(X;14) translocation. Plays a key role in T-cell prolymphocytic leukemia.
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== Function ==
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[https://www.uniprot.org/uniprot/MTCP1_HUMAN MTCP1_HUMAN] Enhances the phosphorylation and activation of AKT1 and AKT2.<ref>PMID:10983986</ref>
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== Evolutionary Conservation ==
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The line below this paragraph, {{ABSTRACT_PUBMED_9520380}}, adds the Publication Abstract to the page
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[[Image:Consurf_key_small.gif|200px|right]]
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(as it appears on PubMed at http://www.pubmed.gov), where 9520380 is the PubMed ID number.
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Check<jmol>
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<jmolCheckbox>
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{{ABSTRACT_PUBMED_9520380}}
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/a1/1a1x_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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==About this Structure==
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<text>to colour the structure by Evolutionary Conservation</text>
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1A1X is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A1X OCA].
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1a1x ConSurf].
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==Reference==
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<div style="clear:both"></div>
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Crystal structure of MTCP-1: implications for role of TCL-1 and MTCP-1 in T cell malignancies., Fu ZQ, Du Bois GC, Song SP, Kulikovskaya I, Virgilio L, Rothstein JL, Croce CM, Weber IT, Harrison RW, Proc Natl Acad Sci U S A. 1998 Mar 31;95(7):3413-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9520380 9520380]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Croce, C M.]]
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[[Category: Croce CM]]
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[[Category: Dubois, G C.]]
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[[Category: Dubois GC]]
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[[Category: Fu, Z Q.]]
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[[Category: Fu ZQ]]
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[[Category: Harrison, R W.]]
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[[Category: Harrison RW]]
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[[Category: Kulikovskaya, I.]]
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[[Category: Kulikovskaya I]]
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[[Category: Rothstein, J.]]
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[[Category: Rothstein J]]
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[[Category: Song, S P.]]
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[[Category: Song SP]]
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[[Category: Virgilio, L.]]
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[[Category: Virgilio L]]
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[[Category: Weber, I T.]]
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[[Category: Weber IT]]
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[[Category: Crystal structure]]
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[[Category: Mtcp-1]]
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[[Category: Oncogene involved in t cell malignancy]]
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[[Category: Proto-oncogene]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jun 30 15:49:09 2008''
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Current revision

CRYSTAL STRUCTURE OF MTCP-1 INVOLVED IN T CELL MALIGNANCIES

PDB ID 1a1x

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